Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism

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	Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism
	Zhang, Limin 1; Wang, Yulan 1,5; Xu, Yunxiang 3; Lei, Hehua 1; Zhao, Ying 1; Li, Huihui 1; Lin, Xiaosheng 2; Chen, Guizhen 2; Tang, Huiru 1,4
刊名	SCIENTIFIC REPORTS
	2014-01-10
卷号	4
英文摘要	Acupoint stimulations are effective in ameliorating symptoms of menopause which is an unavoidable ageing consequence for women. To understand the mechanistic aspects of such treatments, we systematically analyzed the effects of acupoint laser-irradiation and catgut-embedding on the ovariectomy-induced rat metabolic changes using NMR and GC-FID/MS methods. Results showed that ovariectomization (OVX) caused comprehensive metabolic changes in lipid peroxidation, glycolysis, TCA cycle, choline and amino acid metabolisms. Both acupoint laser-irradiation and catgut-embedding ameliorated the OVX-caused metabonomic changes more effectively than hormone replacement therapy (HRT) with nilestriol. Such effects of acupoint stimulations were highlighted in alleviating lipid peroxidation, restoring glucose homeostasis and partial reversion of the OVX-altered amino acid metabolism. These findings provided new insights into the menopause effects on mammalian biochemistry and beneficial effects of acupoint stimulations in comparison with HRT, demonstrating metabonomics as a powerful approach for potential applications in disease prognosis and developments of effective therapies.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	HORMONE REPLACEMENT THERAPY ; AMINO-ACID CATABOLISM ; QUALITY-OF-LIFE ; HIGH-FAT DIET ; POSTMENOPAUSAL WOMEN ; INSULIN SENSITIVITY ; BLOOD-PLASMA ; NITRIC-OXIDE ; HOT FLUSHES ; ACUPUNCTURE
收录类别	SCI
语种	英语
WOS记录号	WOS:000329841700001
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1326]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, Biospect & Metabon Ctr,CAS Key Lab Magnet Resonan, Wuhan Inst Phys & Math,State Key Lab Magnet Reson, Wuhan 430071, Peoples R China 2.Guangzhou Univ Chinese Med, Affiliated BaoAn TCM Hosp, Shenzhen 518101, Peoples R China 3.Guangzhou Univ Chinese Med, Clin Med Coll Acupuncture & Rehabil, Guangzhou 510405, Guangdong, Peoples R China 4.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn Biospect & Metabol, Shanghai 200433, Peoples R China 5.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Limin,Wang, Yulan,Xu, Yunxiang,et al. Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism[J]. SCIENTIFIC REPORTS,2014,4.
APA	Zhang, Limin.,Wang, Yulan.,Xu, Yunxiang.,Lei, Hehua.,Zhao, Ying.,...&Tang, Huiru.(2014).Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism.SCIENTIFIC REPORTS,4.
MLA	Zhang, Limin,et al."Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism".SCIENTIFIC REPORTS 4(2014).