Rapid Diagnosis and Prognosis of de novo Acute Myeloid Leukemia by Serum Metabonomic Analysis

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Rapid Diagnosis and Prognosis of de novo Acute Myeloid Leukemia by Serum Metabonomic Analysis
	Wang, Yihuang 1,2,3,6; Zhang, Limin 4; Chen, Wen-Lian 1,2,3; Wang, Jing-Han 1,2,3; Li, Ning 4; Li, Jun-Min 1,2,3; Mi, Jian-Qing 1,2,3; Zhang, Wei-Na 1,2,3; Li, Yang 1,2,3; Wu, Song-Fang 1,2,3,6
刊名	JOURNAL OF PROTEOME RESEARCH
	2013-10-01
卷号	12 期号:10 页码:4393-4401
关键词	metabonomics NMR acute myeloid leukemia diagnosis prognosis
英文摘要	Acute myeloid leukemia (AML) is a life-threatening hematological disease. Novel diagnostic and prognostic markers will be essential for new therapeutics and for significantly improving associated with AML and search for potential diagnostic and prognostic the disease prognosis. To characterize e metabolic features methods, here we analyzed the phenotypic characteristics of serum metabolite composition (metabonome) in a cohort of 183 patients with de novo acute myeloid leukemia together with 232 age- and gender-matched healthy controls using H-1 NMR spectroscopy in conjunction with multivariate data analysis. We observed significant serum metabonomic differences between AML patients and healthy controls and between AML patients favorable and intermediate cytogenetic risks. Such differences were highlighted by systems differentiations in multiple metabolic pathways including glycolysis/gluconeogenesis, TCA cycle, biosynthesis of proteins and lipoproteins, and metabolism of fatty acids and cell membrane components, especially choline and its phosphorylated derivatives. This demonstrated the NMR-based metabonomics as a rapid and less invasive method for potential AML diagnosis and prognosis. The serum metabolic phenotypes observed here indicated that integration of metabonomics with other techniques will be useful for better understanding the biochemistry of pathogenesis and progression of leukemia.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemical Research Methods
研究领域[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	MAGNETIC-RESONANCE-SPECTROSCOPY ; HUMAN HEPATOCELLULAR-CARCINOMA ; H-1-NMR-BASED METABONOMICS ; PHOSPHOLIPID-METABOLISM ; SYSTEMS BIOLOGY ; BLOOD-PLASMA ; CANCER ; H-1 ; CLASSIFICATION ; METFORMIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000326320300011
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/858]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, State Key Lab Med Genom, Shanghai, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Hematol, Rui Jin Hosp, Shanghai 200030, Peoples R China 4.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Ctr Biospect & Metabon,Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 5.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Zhejiang Inst Hematol, Hangzhou 310003, Zhejiang, Peoples R China 6.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Minist Educ, Key Lab Syst Biomed, Shanghai 200030, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yihuang,Zhang, Limin,Chen, Wen-Lian,et al. Rapid Diagnosis and Prognosis of de novo Acute Myeloid Leukemia by Serum Metabonomic Analysis[J]. JOURNAL OF PROTEOME RESEARCH,2013,12(10):4393-4401.
APA	Wang, Yihuang.,Zhang, Limin.,Chen, Wen-Lian.,Wang, Jing-Han.,Li, Ning.,...&Tang, Huiru.(2013).Rapid Diagnosis and Prognosis of de novo Acute Myeloid Leukemia by Serum Metabonomic Analysis.JOURNAL OF PROTEOME RESEARCH,12(10),4393-4401.
MLA	Wang, Yihuang,et al."Rapid Diagnosis and Prognosis of de novo Acute Myeloid Leukemia by Serum Metabonomic Analysis".JOURNAL OF PROTEOME RESEARCH 12.10(2013):4393-4401.