Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods
	Hou, Zhongyu 1,2; Zhang, Zhonghe 1,2; Meng, Haiwei 1; Lin, Xiangtao 1,3; Sun, Bo 1,3; Lei, Hao 4; Fang, Ke 4; Fang, Fang 4; Liu, Maili 4; Liu, Shuwei 1
刊名	INTERNATIONAL JOURNAL OF NEUROSCIENCE
	2014-02-01
卷号	124 期号:2 页码:125-132
关键词	Parkinson's disease frontal and parietal cortices H-1-MRS
英文摘要	This study aims to investigate metabolic changes in frontal and parietal cortices in the 6-OHDA induced Parkinson's rats. Ratios of N-acetyl-aspartic acid/creatine (NAA/Cr), choline/creatine (Cho/Cr), and glumatic acid and glutamine glutaminic acid/creatine (Glx/Cr) of regions of interests (ROIs) in the frontal and parietal cortices, and the substantia nigra were analyzed. NAA/Cr, Cho/Cr and Glx/Cr in the frontal and parietal cortices in the lesion side did not show any significant differences two weeks after operation compared with the contralateral side (p > 0.05). NAA/Cr in the frontal cortex in the lesion side was significantly lower in the five weeks after operation; Cho/Cr remained normal; Glx/Cr increased (p < 0.05), and all ratios of parietal cortex were normal. In the eight weeks after operation, NAA/Cr in the frontal cortex in the lesion side was lower than that of the five weeks (p < 0.01), Cho/Cr still remained normal while Glx/Cr was higher than before (p < 0.01). Regarding the parietal cortex, NAA/Cr increased significantly, while Cho/Cr and Glx/Cr remained normal. In the 12 weeks after operation, NAA/Cr, Cho/Cr and Glx/Cr in frontal cortex were consistent with that of the eight weeks, while they remained at the normal level in parietal cortex. The NAA/Cr in the substantia nigra decreased and Cho/Cr increased significantly during 2-8 weeks, and remained at the same level during 8-12 weeks. There are metabolic disturbances in PD rats. The transient hyperfunction in the parietal cortex can be considered as a compensation for the dysfunction of the frontal cortex and substantia nigra.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	MAGNETIC-RESONANCE-SPECTROSCOPY ; PROGRESSIVE SUPRANUCLEAR PALSY ; MULTIPLE SYSTEM ATROPHY ; FUNCTIONAL MRI ; CORTEX
收录类别	SCI
语种	英语
WOS记录号	WOS:000329830000009
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1282]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Shandong Univ, Sch Med, Res Ctr Sect & Imaging Anat, Jinan 250012, Shandong, Peoples R China 2.Shandong Univ, Shandong Prov Hosp, Dept Med Imaging, Jinan 250012, Shandong, Peoples R China 3.Shandong Med Imaging Res Inst, Dept Radiol, Jinan, Shandong, Peoples R China 4.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Hou, Zhongyu,Zhang, Zhonghe,Meng, Haiwei,et al. Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods[J]. INTERNATIONAL JOURNAL OF NEUROSCIENCE,2014,124(2):125-132.
APA	Hou, Zhongyu.,Zhang, Zhonghe.,Meng, Haiwei.,Lin, Xiangtao.,Sun, Bo.,...&Liu, Shuwei.(2014).Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods.INTERNATIONAL JOURNAL OF NEUROSCIENCE,124(2),125-132.
MLA	Hou, Zhongyu,et al."Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods".INTERNATIONAL JOURNAL OF NEUROSCIENCE 124.2(2014):125-132.