NMR-based Metabonomic Study on Rat's Urinary Metabolic Response to Dosage of Triptolide

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	NMR-based Metabonomic Study on Rat's Urinary Metabolic Response to Dosage of Triptolide
	Xia Shengan 1,2; Liu Huilang 1,2; Zhu Hang 1,2; Zhou Zhiming 1,2; Zhang Xu 1; Liu Maili 1
刊名	CHINESE JOURNAL OF CHEMISTRY
	2009-04-01
卷号	27 期号:4 页码:751-758
关键词	NMR triptolide principal component analysis urine
通讯作者	Liu, ML (reprint author), Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China.
英文摘要	An NMR-based metabonomic approach was used to examine rat's urinary response to dosage of triptolide (TP), a major component responsible for the immunosuppressive and anti-inflammatory effects of Tripterygium wilfordii Hook F (TWHF). The urine samples of Wistar rats were collected at various time intervals before and after dosage of TP (i.p.) and measured using conventional (1)H NMR spectroscopy. The data were statistically analyzed using a principle component analysis (PCA). The results showed that biochemical variation induced by TP was time-related, and the maximal alteration in the metabolites appeared at 16 h, and partially recovered 56 It later after dosage. Increment in relative concentrations of taurine, creatine, trimethylamine N-oxide and decrement in citrate, succinate, 2-oxoglutarate and hippurate were observed in the urine after dosage of TP. In addition, 2'-deoxycytidine appeared 0-16 h later after the dosage, which may be considered as another biomarker for the acute hepatotoxicity. It suggested that TP may disturb the metabolism of energy and gut microflora, and may cause acute liver lesion and a slight renal impair. These results were also supported by the conventional analysis of clinical plasma chemistry and histopathology. The information observed in this article may be useful for giving insight into mechanism of liver injury induced by TP.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	COLLAGEN-INDUCED ARTHRITIS ; PATTERN-RECOGNITION ; TRIPTERYGIUM-WILFORDII ; MAGNETIC-RESONANCE ; TOXICITY ; H-1-NMR ; EXCRETION ; DISEASE ; CLASSIFICATION ; HEPATOTOXICITY
收录类别	SCI
语种	英语
WOS记录号	WOS:000265717900024
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/2243]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xia Shengan,Liu Huilang,Zhu Hang,et al. NMR-based Metabonomic Study on Rat's Urinary Metabolic Response to Dosage of Triptolide[J]. CHINESE JOURNAL OF CHEMISTRY,2009,27(4):751-758.
APA	Xia Shengan,Liu Huilang,Zhu Hang,Zhou Zhiming,Zhang Xu,&Liu Maili.(2009).NMR-based Metabonomic Study on Rat's Urinary Metabolic Response to Dosage of Triptolide.CHINESE JOURNAL OF CHEMISTRY,27(4),751-758.
MLA	Xia Shengan,et al."NMR-based Metabonomic Study on Rat's Urinary Metabolic Response to Dosage of Triptolide".CHINESE JOURNAL OF CHEMISTRY 27.4(2009):751-758.