Systems Biological Responses to Chronic Perfluorododecanoic Acid Exposure by Integrated Metabonomic and Transcriptomic Studies

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Systems Biological Responses to Chronic Perfluorododecanoic Acid Exposure by Integrated Metabonomic and Transcriptomic Studies
	Ding, Lina 1,3; Hao, Fuhua2 ; Shi, Zhimin 1; Wang, Yulan 2; Zhang, Hongxia 1; Tang, Huiru 2; Dai, Jiayin 1
刊名	JOURNAL OF PROTEOME RESEARCH
	2009-06-01
卷号	8 期号:6 页码:2882-2891
关键词	hepatotoxicology metabonomics perfluorododecanoic acid systems biology toxicogenomics
通讯作者	Dai, JY (reprint author), Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China.
英文摘要	Perfluorocarboxylic acids (PFCAs) have been widely used in consumer and industrial products, such as food packaging, and found in the blood of both humans and wildlife. Although studies showed a high tendency toward biological accumulation and a variety of toxic effects for PFCAs, the mechanistic aspects of their toxicity remain unknown. In present study, we investigated the dosage-dependent metabonomic and transcriptomic responses of male rats to the exposure to perfluorododecanoic acid (PFDoA) over 110 days. Our NMR-based metabonomics results for both liver tissues and serum demonstrated that PFDoA exposure led to hepatic lipidosis, which was characterized by a severe elevation in hepatic triglycerides and a decline in serum lipoprotein levels. The results from transcriptomic changes induced by PFDoA corroborated these results with changes in gene transcript levels associated with fatty acid homeostasis. These results demonstrate that PFDoA induces hepatic steatosis via perturbations to fatty acid uptake, lipogenesis, and fatty acid oxidation. Several serum metabolites exhibited dose-dependences, providing thorough descriptions of changes induced by PFDoA exposure. These observations yielded novel insights regarding the toxicological mechanism of PFCAs at the systems level.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemical Research Methods
研究领域[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	CARBON-CHAIN LENGTH ; PERFLUORINATED ORGANIC-COMPOUNDS ; PEROXISOME PROLIFERATION ; NMR-SPECTROSCOPY ; GENE-EXPRESSION ; FATTY-ACIDS ; PERFLUOROOCTANE SULFONATE ; APOLIPOPROTEIN-M ; MOUSE-LIVER ; TOXICITY
收录类别	SCI
语种	英语
WOS记录号	WOS:000266719400024
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/2214]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ding, Lina,Hao, Fuhua,Shi, Zhimin,et al. Systems Biological Responses to Chronic Perfluorododecanoic Acid Exposure by Integrated Metabonomic and Transcriptomic Studies[J]. JOURNAL OF PROTEOME RESEARCH,2009,8(6):2882-2891.
APA	Ding, Lina.,Hao, Fuhua.,Shi, Zhimin.,Wang, Yulan.,Zhang, Hongxia.,...&Dai, Jiayin.(2009).Systems Biological Responses to Chronic Perfluorododecanoic Acid Exposure by Integrated Metabonomic and Transcriptomic Studies.JOURNAL OF PROTEOME RESEARCH,8(6),2882-2891.
MLA	Ding, Lina,et al."Systems Biological Responses to Chronic Perfluorododecanoic Acid Exposure by Integrated Metabonomic and Transcriptomic Studies".JOURNAL OF PROTEOME RESEARCH 8.6(2009):2882-2891.