Synthesis, Characterization, and in Vitro pH-Controllable Drug Release from Mesoporous Silica Spheres with Switchable Gates

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Synthesis, Characterization, and in Vitro pH-Controllable Drug Release from Mesoporous Silica Spheres with Switchable Gates
	Gao, Qiang 1,2; Xu, Yao 1; Wu, Dong 1; Shen, Wanling 3; Deng, Feng 3
刊名	LANGMUIR
	2010-11-16
卷号	26 期号:22 页码:17133-17138
产权排序	第三
英文摘要	To accomplish pH-controllable drug release on mesoporous carrier, one of the best ways is to graft stimuli-responsive organic molecules around mesopore outlets. In this work, the pH-responsive propyldiethylenetriamine groups (abbreviative phrase: multiamine chains) were grafted around mesopore outlets of mesoporous silica spheres (MSS) and expected to act as pH-responsive gates. To this end, three multiamine-grafted MSS (i.e., NM1, NM2, and NM3) were synthesized under different reaction temperatures and reaction times. The reaction temperature and time for multiamine grafting were 25 degrees C and 12h for NM1, 100 degrees C and 1 h for NM2, and 100 degrees C and 12h for NM3. respectively. Through systematic investigations of TEM, SEM, N-2 adsorption/desorption, TG, and Si-29 NI AS NMR, it was found that NM3 had the highest grafting amount of multiamine chains. It was further confirmed that the multiamine chains around the pore outlets of NM3 played the role of "molecular switch" that could well control the transport of guest drug molecules. In contrast, the multiamine chains around the pore outlets of NM2 and NM3 did not show gate effect. The difference should be decided by the fact whether the grafting amount of multiamine chains around mesopore outlets were sufficient under determined reaction temperature and time. In the tests of in vitro drug release, multiamine-gated MSS (i.e., NM3) showed highly sensitive response to the solution pH. At high pH (pH 7.5), ibuprofen (IBU) in this carrier released rapidly and completely within 2 h; at low pH (pH 4.0 or 5.0), only a small part of the IBU (13 wt %) was slowly released from this carrier anti the most of IOU was effectively confined in mesopores.
学科主题	波谱分析
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]	Chemistry ; Materials Science
关键词[WOS]	RESPONSIVE CONTROLLED-RELEASE ; GUEST MOLECULES ; DELIVERY-SYSTEM ; MCM-41 ; NANOPARTICLES ; SURFACE ; SIEVES
收录类别	SCI
语种	英语
WOS记录号	WOS:000283837800068
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/2066]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, State Key Lab Coal Convers, Inst Coal Chem, Taiyuan 030001, Peoples R China 2.China Univ Geosci, Dept Fac Mat Sci & Chem Engn, Wuhan 430074, Peoples R China 3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Gao, Qiang,Xu, Yao,Wu, Dong,et al. Synthesis, Characterization, and in Vitro pH-Controllable Drug Release from Mesoporous Silica Spheres with Switchable Gates[J]. LANGMUIR,2010,26(22):17133-17138.
APA	Gao, Qiang,Xu, Yao,Wu, Dong,Shen, Wanling,&Deng, Feng.(2010).Synthesis, Characterization, and in Vitro pH-Controllable Drug Release from Mesoporous Silica Spheres with Switchable Gates.LANGMUIR,26(22),17133-17138.
MLA	Gao, Qiang,et al."Synthesis, Characterization, and in Vitro pH-Controllable Drug Release from Mesoporous Silica Spheres with Switchable Gates".LANGMUIR 26.22(2010):17133-17138.