Total synthesis of solamargine

	Total synthesis of solamargine
	Wei, Guohua ; Wang, Jing ; Du, Yuguo
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2011-05-15
卷号	21 期号:10 页码:2930—2933
中文摘要	Solamargine, (25R)-3 beta-{O-alpha-L-rhamnopyranosyl-(1 -> 2)-[O-alpha-L-rhamnopyranosyl-(1 -> 4)]-beta-D-glucopyranosyloxy}-22 alpha-N-spirosol-5-ene, has been synthesized in 13 steps in a 10.5% overall yield starting from the naturally abundant diosgenin. Condensation of a partially protected glucopyranosyl donor with an oxaza-spiro moiety, which was formed in one-pot azido reduction, significantly improved the synthesis of desired molecule. The target compound exhibited good cytotoxic activities against tumor cells HeLa, A549, MCF-7, K562, HCT116, U87, and HepG2 with IC(50) ranging from 2.1 to 8.0 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
公开日期	2012-10-18
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/7060]
专题	生态环境研究中心_中国科学院环境生物技术重点实验室
推荐引用方式 GB/T 7714	Wei, Guohua,Wang, Jing,Du, Yuguo. Total synthesis of solamargine[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(10):2930—2933.
APA	Wei, Guohua,Wang, Jing,&Du, Yuguo.(2011).Total synthesis of solamargine.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(10),2930—2933.
MLA	Wei, Guohua,et al."Total synthesis of solamargine".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.10(2011):2930—2933.