Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity
	Cao, Tuan-Wu 1; Geng, Chang-An1 ; Ma, Yun-Bao 1; Zhang, Xue-Mei1 ; Zhou, Jun1 ; Tao, Yan-Duo 2; Chen, Ji-Jun1
刊名	FITOTERAPIA
	2015-04-01
卷号	102 页码:15-22
关键词	Swertia mussotii Gentianaceae Chemical constituents (-)-swermusic acid A and B (-)-swerimuslatone A Anti-HBV activity
英文摘要	Three new secoiridoid aglycones of (-)-swermusic acid A (1) and B (3), and (-)-swerimuslatone A (2), and four new secoiridoid glycosides of 6'-O-formylsweroside (4),6'-O-formylgentiopicroside (5), 6'-O-acetylamarogentin (6) and 6'-O-acetylamaronitidin (7), along with 40 known compounds (8-47) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses including MS, IR, UV, 1D- and 2D-NMR. Forty-five compounds from S. mussotii were evaluated for their anti-HBV activity on the HepG 2.2.15 cell line in vitro inhibiting the secretions of HBsAg and HBeAg, as well as HBV DNA replication. Six of the nine phenols 26-29,31 and 32 exhibited activities inhibiting HBsAg and HBeAg secretion with IC50 values from 0.23 to 5.18 mM, and HBV DNA replication with IC50 values from <0.06 to 2.62 mM. Moreover, isooriention (45) displayed significant anti-HBV activities against secretions of HBsAg and HBeAg with IC50 value of 0.79 and 1.12 mM, as well as HBV DNA replication with IC50 value of 0.02 mM. (C) 2015 Elsevier B.V. All rights reserved.
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	SECOIRIDOID GLYCOSIDES ; GENTIANA ; TRITERPENOIDS ; DISEASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000353742600003
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/20690]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Res Ctr Biol Resources Qinghai Tibet Plateau, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Cao, Tuan-Wu,Geng, Chang-An,Ma, Yun-Bao,et al. Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity[J]. FITOTERAPIA,2015,102:15-22.
APA	Cao, Tuan-Wu.,Geng, Chang-An.,Ma, Yun-Bao.,Zhang, Xue-Mei.,Zhou, Jun.,...&Chen, Ji-Jun.(2015).Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity.FITOTERAPIA,102,15-22.
MLA	Cao, Tuan-Wu,et al."Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity".FITOTERAPIA 102(2015):15-22.