Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice
	Yao, Ran 1,2; Chen, Zhaoli 1,2; Zhou, Chengcheng 1,2; Luo, Mei 1,2; Shi, Xuejiao 1,2; Li, Jiagen 1,2; Gao, Yibo 1,2; Zhou, Fang 1,2; Pu, Jianxin3 ; Sun, Handong3
刊名	JOURNAL OF NATURAL PRODUCTS
	2015
卷号	78 期号:1 页码:10-16
通讯作者	Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; pujianxin@mail.kib.ac.cn ; prof_jiehe@163.com
英文摘要	Esophageal cancer is the eighth most common cancer in the world and ranks as the sixth leading cause of cancer-related mortality. Esophageal cancer has a poor prognosis partially due to its low sensitivity to chemotherapy agents, and the development of new therapeutic agents is urgently needed. Here, the antitumor activity of a natural ent-kaurane diterpenoid, xerophilusin B (1), which was isolated from Isodon xerophilus, a perennial herb frequently used in Chinese folk medicine for tumor treatment, was investigated. Compound 1 exhibited antiproliferative effects against esophageal squamous cell carcinoma (ESCC) cell lines in a time- and dose-dependent manner with lower toxicity against normal human and murine cell lines. In vivo studies demonstrated that 1 inhibited tumor growth of a human esophageal tumor xenograft in BALB/c nude mice without significant secondary adverse effects, indicating its safety in treating ESCC. Furthermore, 1 induced G2/M cell cycle arrest and promoted apoptosis through mitochondrial cytochrome c-dependent activation of the caspase-9 and caspase-3 cascade pathway in ESCC cell lines. In conclusion, the observations herein reported showed that 1 is a potential chemotherapeutic agent for ESCC and merits further preclinical and clinical investigation for cancer drug development.
学科主题	Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	CYTOTOXIC ENT-KAURANOIDS ; NF-KAPPA-B ; RABDOSIA-RUBESCENS ; CANCER-CELLS ; ISODON-XEROPHILUS ; DITERPENOIDS ; DEATH ; CHEMORADIOTHERAPY ; ACTIVATION ; PONICIDIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000348617800003
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/20622]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Peking Union Med Coll, Canc Inst & Hosp, Dept Thorac Surg, Beijing 100021, Peoples R China 2.Chinese Acad Med Sci, Beijing 100021, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yao, Ran,Chen, Zhaoli,Zhou, Chengcheng,et al. Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(1):10-16.
APA	Yao, Ran.,Chen, Zhaoli.,Zhou, Chengcheng.,Luo, Mei.,Shi, Xuejiao.,...&He, Jie.(2015).Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice.JOURNAL OF NATURAL PRODUCTS,78(1),10-16.
MLA	Yao, Ran,et al."Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice".JOURNAL OF NATURAL PRODUCTS 78.1(2015):10-16.