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	Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens
	Liu, Xu1; Zhan, Rui2; Wang, Wei Guang2; Du, Xue2; Li, Yan2; Zhang, Peng1; Pu, Jian Xin2; Wu, Ji Zhou1; Sun, Han Dong2
刊名	ARCHIVES OF PHARMACAL RESEARCH
	2012-12-01
卷号	35期号:12页码:2147-2151
关键词	Jianshirubesins D-F 11 Isodon rubescens Cytotoxicity 20-Epoxy-ent-kauranoids
英文摘要	Three rare and new 11,20-epoxy-ent-kaurane diterpenoids, named jianshirubesins D-F (1-3), along with one known analogue (4), were isolated from the aerial parts of Isodon rubescens. Their structures were established by analysis of spectroscopic data. Found in the MTT assay to evaluate the cytotoxicity of compounds 1, 2, and 4, only 1 could selectively inhibit certain cell lines from proliferating. In addition, a simple structure-activity relationship discussion might suggest a new bioactive moiety, different from the alpha,beta-unsaturated ketone group.
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	ABIETANE DITERPENOIDS ; VAR.-LUSHIENSIS ; CYTOTOXICITY ; CONSTITUENTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000312772900012
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/20443]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Tongji Sch Pharm, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xu,Zhan, Rui,Wang, Wei Guang,et al. Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens[J]. ARCHIVES OF PHARMACAL RESEARCH,2012,35(12):2147-2151.
APA	Liu, Xu.,Zhan, Rui.,Wang, Wei Guang.,Du, Xue.,Li, Yan.,...&Sun, Han Dong.(2012).Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens.ARCHIVES OF PHARMACAL RESEARCH,35(12),2147-2151.
MLA	Liu, Xu,et al."Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens".ARCHIVES OF PHARMACAL RESEARCH 35.12(2012):2147-2151.

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