吗啡戒断对大鼠空间学习及反应学习的影响

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理研究所回溯数据库(1956-2010)

	吗啡戒断对大鼠空间学习及反应学习的影响
	隋南; 隋南; 隋南; 隋南; 李勇辉; 隋南; 隋南; 隋南; 隋南; 隋南
刊名	中华行为医学与脑科学杂志
	2009
通讯作者邮箱	suin@psych.ac.cn
卷号	18 期号:6 页码:523-525
关键词	空间学习反应学习吗啡戒断奖赏效应
其他题名	Effects of morphine withdrawal on place learning and response learning in rats
通讯作者	隋南
产权排序	1
合作状况	国内
中文摘要	目的观察在经历特定剂量吗啡前期用药后的停药状态下,大鼠空间学习和反应学习过程的改变.方法在前期用药阶段,戒断组及持续给药组皮下注射吗啡5 mg·kg-1·d-1,连续6 d,盐水组在相同时间注射生理盐水,之后,各组进行水迷宫空间学习任务或反应学习任务.在训练期间,戒断组和盐水组每天注射盐水,持续给药组连续给药.结果空间学习任务中,在训练第3轮,各组正确率分别为戒断组[(97.0±6.0)%]、持续给药组[(79.9±20.1)%]、盐水组[(61.0±20.6)%],戒断组显著高于盐水组( P <0.01 post-hoc LSD test),重复测试显示,戒断组空间学习显著优于盐水组( P <0.05),在空间反向任务中,戒断组表现亦显著优于盐水组.反应学习任务及反应反向学习任务中,各组间差异无显著性.结论本研究提示在吗啡戒断状态下大鼠空间学习过程增强.
英文摘要	Objective To investigate the effects of morphine withdrawal on place learning and response learning in rat. Methods 48 wistar rats were divided into morphine-withdrawal group,morphine-maintenance group and saline group. First,the morphine-withdrawal group and morphine-maintenance group both received morphine pretreatment (SC 5mg.kg-1.day-1) for 6 days,and the saline group received saline injection in the same time. Then all the animals were trained with the place learning task or the response learning task in water plus maze. The morphine-maintenance group received morphine daily between two trains,and the morphine-withdrawal groups and saline group received saline in the same time. Results In the place learning task ,the correction rate of the morphine-withdrawal group,morphine-maintenance group and saline group was (97.0±6.0)%,(79.9±20.1)% and (61.0±20.6)% respectively .The difference between morphine-withdrawal group and saline group was significantly ( P <0.01 ).Accordingly,the difference in training effect was significant between these two groups by repeated measure with analysis of variance ( F =31.196,P <0.01). Resemble results were found in the place reverse learning task. There was no significant difference in three groups in response learning task and response reverse learning task. Conclusion Morphine withdrawal may increase place learning,with no significant improvement in response learning.
学科主题	医学心理学
收录类别	CSCD
资助信息	国家重点基础研究发展“973”计划；国家自然科学基金项目
原文出处	http://d.g.wanfangdata.com.hk/Periodical_zgxwyxkx200906015.aspx
语种	中文
CSCD记录号	CSCD:3628449
公开日期	2014-05-23
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10005]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	隋南; 隋南; 隋南; 隋南; 隋南; 隋南; 隋南; 隋南; 隋南; 隋南
推荐引用方式 GB/T 7714	隋南,隋南,隋南,等. 吗啡戒断对大鼠空间学习及反应学习的影响[J]. 中华行为医学与脑科学杂志,2009,18(6):523-525.
APA	隋南.,隋南.,隋南.,隋南.,李勇辉.,...&隋南.(2009).吗啡戒断对大鼠空间学习及反应学习的影响.中华行为医学与脑科学杂志,18(6),523-525.
MLA	隋南,et al."吗啡戒断对大鼠空间学习及反应学习的影响".中华行为医学与脑科学杂志 18.6(2009):523-525.