Altered brain structure in Chinese dyslexic children

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	Altered brain structure in Chinese dyslexic children
	Liu, Li1 ; You, Wenping2 ; Wang, Wenjing 1; Guo, Xiaojuan 1,3; Peng, Danling 1; Booth, James 4
刊名	NEUROPSYCHOLOGIA
	2013
卷号	51 期号:7 页码:1169-1176
关键词	Chinese dyslexia Voxel-based morphometry Memory encoding and retrieval
ISSN号	0960-2011
通讯作者	Liu, L (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
产权排序	2
英文摘要	Due to the logographic nature of the writing system, learning to read Chinese places heavy demands on encoding of orthographic forms through rote memorization. Moreover, phonology has to often be retrieved from memory during reading because of the inconsistent mapping between characters and their pronunciations. Using optimized voxel-based morphometry, we examined differences in volumetrics between children with reading disability (RD, 10-12 years old) and age-matched typically developing (TD) children. Our study shows reduced gray matter volume (GMV) for RD in right inferior occipital gyrus and left inferior frontal gyrus, consistent with previous studies suggesting that Chinese dyslexics have deficits in orthographic and phonological processing. The deficit in phonological processing was further supported by reductions in white matter volumes (WMV) in left precentral gyrus. Greater deficits in ortho-phonological processing may be associated with semantic compensation, as lower skill RD children showed greater GMV in anterior temporal cortex, even though as a group they showed less GMV in this region compared to TD. Perhaps most interestingly, we showed reduced GMV in bilateral ventromedial prefrontal cortices (vmPFC) and this was correlated with reductions in WMV within vmPFC, suggesting that RD have deficits in memory retrieval. Moreover, these GMV alterations in vmPFC for the RD were correlated with alterations in right parahippocampal gyrus, which also showed a reduced GMV, suggesting that RD have a correlated deficit in memory encoding. Our results ire consistent with previous studies suggesting that Chinese dyslexics have deficits in visuo-orthographic and phonological processing, but our study importantly suggests deficits in memory encoding and retrieval, perhaps due to the unique demands of the Chinese writing system. (C) 2013 Elsevier Ltd. All rights reserved.
学科主题	Cognitive psychology，Developmental psychology
WOS标题词	Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
类目[WOS]	Behavioral Sciences ; Neurosciences ; Psychology, Experimental
研究领域[WOS]	Behavioral Sciences ; Neurosciences & Neurology ; Psychology
关键词[WOS]	INFERIOR PREFRONTAL CORTEX ; VOXEL-BASED MORPHOMETRY ; DEVELOPMENTAL DYSLEXIA ; GRAY-MATTER ; CONTEXTUAL FACILITATION ; DEFICIT HYPOTHESIS ; FUNCTIONAL-ANATOMY ; MEMORY ; LANGUAGE ; READERS
收录类别	SSCI
项目简介	This study was supported by grants from Chinese National Natural Science Foundation (31000500, 81000603 and 81171016), the Fundamental Research Funds for the Central Universities, Beijing Natural Science Foundation (7102089) and the United States National Institute of Child Health and Human Development (HD042049).
原文出处	http://www2.communication.northwestern.edu/departments/csd/research/developmental_cognitive_neuroscience/documents/LiuYou.NP.2013.pdf
语种	英语
WOS记录号	WOS:000321539400004
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10785]
专题	心理研究所_中国科学院行为科学重点实验室
作者单位	1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 3.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing 100875, Peoples R China 4.Northwestern Univ, Dept Commun Sci & Disorders, Evanston, IL 60208 USA
推荐引用方式 GB/T 7714	Liu, Li,You, Wenping,Wang, Wenjing,et al. Altered brain structure in Chinese dyslexic children[J]. NEUROPSYCHOLOGIA,2013,51(7):1169-1176.
APA	Liu, Li,You, Wenping,Wang, Wenjing,Guo, Xiaojuan,Peng, Danling,&Booth, James.(2013).Altered brain structure in Chinese dyslexic children.NEUROPSYCHOLOGIA,51(7),1169-1176.
MLA	Liu, Li,et al."Altered brain structure in Chinese dyslexic children".NEUROPSYCHOLOGIA 51.7(2013):1169-1176.