Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats

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	Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats
	Wu, Yan 1,2; Li, Yonghui1 ; Gao, Jun1,2 ; Sui, Nan1
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2012-01-15
卷号	674 期号:2-3 页码:321-326
关键词	Reconsolidation Morphine Appetitive and aversive memory NMDA receptor Nucleus accumbens
ISSN号	0014-2999
通讯作者	Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
产权排序	1
英文摘要	Dysfunctional reconsolidation processes may help drug memories resist extinction and contribute to high rate of relapse. Reconsolidation of drug memory is mainly affected by the appetitive and aversive emotional experiences associated with an addictive drug. The nucleus accumbens has been shown to mediate the reconsolidation of positive emotional addictive memory, but its role in negative emotional addictive memory remains elusive. In the present study, we used morphine-induced CPP (m-CPP) and morphine-naloxone induced conditioned place aversion (m-CPA) to investigate the role of N-methyl-D-aspartate (NMDA) receptors within the nucleus accumbens on reconsolidation of emotional drug memory. Here we demonstrate that infusion of the NMDA receptor antagonist, D-(-)-2 amino-5-phosphonopentanoic acid ((D)-APV). into the nucleus accumbens before memory reactivation disrupts the reconsolidation of m-CPP, but does not affect m-CPA. The effect on m-CPP reconsolidation depended on memory reactivation: (D)-APV infusion had no effect in the absence of reactivation. The findings show that the glutamatergic NMDA receptor in nucleus accumbens mechanisms involved in reconsolidating aversive and positive morphine-associated memories can be dissociated. (C) 2011 Elsevier B.V. All rights reserved.
学科主题	Cognitive psychology
收录类别	SCI
项目简介	This work was supported by the National Basic Research Program Grant (2009CB522002), the Chinese Academy of Sciences Grant (KSCX2-EW-R-12), and National Natural Science Foundation Grants (30600184, 31070911). We thank Professor Stephen Brimijoin for his critical reading and revision.
语种	英语
WOS记录号	WOS:000300200000032
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/11464]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Yan,Li, Yonghui,Gao, Jun,et al. Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2012,674(2-3):321-326.
APA	Wu, Yan,Li, Yonghui,Gao, Jun,&Sui, Nan.(2012).Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats.EUROPEAN JOURNAL OF PHARMACOLOGY,674(2-3),321-326.
MLA	Wu, Yan,et al."Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats".EUROPEAN JOURNAL OF PHARMACOLOGY 674.2-3(2012):321-326.