Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility

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	Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility
	Snyder, Kevin 2; Wang, Wei-Wen3 ; Han, Rebecca 2; McFadden, Kile 1; Valentino, Rita J.1
刊名	NEUROPSYCHOPHARMACOLOGY
	2012
卷号	37 期号:2 页码:520-530
关键词	stress set shifting behavioral flexibility prefrontal cortex reversal learning norepinephrine
ISSN号	0893-133X
通讯作者	Valentino, RJ (reprint author), Childrens Hosp Philadelphia, Abramson Pediat Res Ctr 402D, Dept Anesthesiol & Crit Care Med, Philadelphia, PA 19104 USA.
产权排序	2
英文摘要	Corticotropin-releasing factor (CRF), the stress-related neuropeptide, acts as a neurotransmitter in the brain norepinephrine nucleus, locus coeruleus (LC), to activate this system during stress. CRF shifts the mode of LC discharge from a phasic to a high tonic state that is thought to promote behavioral flexibility. To investigate this, the effects of CRF administered either intracerebroventricularly (30-300 ng, i.c.v.) or directly into the LC (intra-LC; 2-20 ng) were examined in a rat model of attentional set shifting. CRF differentially affected components of the task depending on dose and route of administration. Intracerebroventricular CRF impaired intradimensional set shifting, reversal learning, and extradimensional set shifting (EDS) at different doses. In contrast, intra-LC CRF did not impair any aspect of the task. The highest dose of CRF (20 ng) facilitated reversal learning and the lowest dose (2 ng) improved EDS. The dose-response relationship for CRF on EDS performance resembled an inverted U-shaped curve with the highest dose having no effect. Intra-LC CRF also elicited c-fos expression in prefrontal cortical neurons with an inverted U-shaped dose-response relationship. The number of c-fos profiles was positively correlated with EDS performance. Given that CRF excites LC neurons, the ability of intra-LC CRF to activate prefrontal cortical neurons and facilitate EDS is consistent with findings implicating LC-norepinephrine projections to medial prefrontal cortex in this process. Importantly, the results suggest that CRF release in the LC during stress facilitates shifting of attention between diverse stimuli in a dynamic environment so that the organism can adapt an optimal strategy for coping with the challenge. Neuropsychopharmacology (2012) 37, 520-530; doi:10.1038/npp.2011.218; published online 12 October 2011
学科主题	Cognitive neuroscience
收录类别	SCI
项目简介	This research was supported by PHS Grant MH40008, DA09082, MH14654 (KS), ARO 58077-LS-DRP (S Bhatnagar), National Basic Research Program of China (2007CB512306), Institute of Psychology Beijing (09CX133013), and the Chinese Academy of Sciences (KSCX2-EW-J-8). We acknowledge the assistance of Rosemary Trumbull and statistical consultation with Nayla Chaijale.
原文出处	http://www.nature.com/npp/journal/v37/n2/pdf/npp2011218a.pdf
语种	英语
WOS记录号	WOS:000298342500022
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/11456]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Childrens Hosp Philadelphia, Abramson Pediat Res Ctr 402D, Dept Anesthesiol & Crit Care Med, Philadelphia, PA 19104 USA 2.Univ Penn, Philadelphia, PA 19104 USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Snyder, Kevin,Wang, Wei-Wen,Han, Rebecca,et al. Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility[J]. NEUROPSYCHOPHARMACOLOGY,2012,37(2):520-530.
APA	Snyder, Kevin,Wang, Wei-Wen,Han, Rebecca,McFadden, Kile,&Valentino, Rita J..(2012).Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility.NEUROPSYCHOPHARMACOLOGY,37(2),520-530.
MLA	Snyder, Kevin,et al."Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility".NEUROPSYCHOPHARMACOLOGY 37.2(2012):520-530.