Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis

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	Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis
	Qian, Gui-min 2; Pan, Guo-Feng 3; Guo, Jian-You1
刊名	NATURAL PRODUCT RESEARCH
	2012
卷号	26 期号:24 页码:2358-2362
关键词	cordymin anti-inflammatory antinociceptive TNF-alpha IL-1 beta TAOS neurolysin
ISSN号	1478-6419
通讯作者	Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
产权排序	3
英文摘要	The anti-inflammatory and antinociceptive activities of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, were studied. The effects of cordymin on cytokine levels and total antioxidant activity were analysed. The antinociceptive effects of cordymin in vivo and in vitro were also determined. Cordymin treatment decreased the levels of tumour necrosis factor alpha, interleukin 1 beta and total antioxidant status. Cordymin inhibited the acetic acid-induced abdominal constrictions in mice in a dose-dependent manner. In the hot-plate test, results showed that cordymin significantly inhibited the reaction time to thermal stimuli at 30, 60 and 90 min. In neurolysin inhibition assay, cordymin showed strong activities against neurolysin (IC50 = 0.1 mu M). Our results show that cordymin is a potent anti-inflammatory and analgesic medicine.
学科主题	Medical psychology
收录类别	SCI
项目简介	This project was supported by NNSF grant (30800301, 31170992), the Key New Drugs Innovation project from Ministry of Science and Technology (2010ZX09102-201-018), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).
原文出处	http://www.tandfonline.com/doi/pdf/10.1080/14786419.2012.658800
语种	英语
WOS记录号	WOS:000310608200013
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/11405]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Zhejiang Pharmaceut Coll, Dept Tradit Chinese Med, Ningbo 315100, Zhejiang, Peoples R China 3.Capital Med Univ, Beijing Shijitan Hosp, Dept Tradit Chinese Med, Beijing 100038, Peoples R China
推荐引用方式 GB/T 7714	Qian, Gui-min,Pan, Guo-Feng,Guo, Jian-You. Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis[J]. NATURAL PRODUCT RESEARCH,2012,26(24):2358-2362.
APA	Qian, Gui-min,Pan, Guo-Feng,&Guo, Jian-You.(2012).Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis.NATURAL PRODUCT RESEARCH,26(24),2358-2362.
MLA	Qian, Gui-min,et al."Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis".NATURAL PRODUCT RESEARCH 26.24(2012):2358-2362.