PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors

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	PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors
	Wang, Li1 ; Cao, Chengqi 1,2; Wang, Richu1,2 ; Qing, Yulan 1,2; Zhang, Jianxin1 ; Zhang, Xiang Yang 3
刊名	JOURNAL OF AFFECTIVE DISORDERS
	2013
卷号	150 期号:1 页码:156-159
关键词	PTSD PAC1 receptor Single-nucleotide polymorphism Association study
ISSN号	0165-0327
通讯作者	Wang, L (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
产权排序	1
英文摘要	Background: Genetic factors are important in the development of posttraumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder remain largely unresolved. The present study investigated the association between ADCYAP1R1 rs2267735 genotype and PTSD symptoms in a highly traumatized sample of Chinese adults. Methods: Participants included 326 victims who experienced 2008 Wenchuan earthquake and lost their children during the disaster. PTSD symptoms were assessed with the PTSD Checklist (PCL). The ADCYAP1R1 rs2267735 SNP was genotyped with the Sequenom iPlex chemistries and the MassARRAY system. Results: The results indicated that although the rs2267735 'CC' genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's emotional numbing symptoms in women. Limitations: A relatively small sample exposed to specific traumatic events was used, and PTSD was assessed using a self-reported instrument. Conclusions: The findings suggest that the PACAP-PAC1 receptor pathway may play an important role in female human responses to traumatic stress, and carry implications for better understanding and treating of posttraumatic psychopathology. (C) 2013 Elsevier B.V. All rights reserved.
学科主题	Trauma psychology
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Clinical Neurology ; Psychiatry
研究领域[WOS]	Neurosciences & Neurology ; Psychiatry
关键词[WOS]	POSTTRAUMATIC-STRESS-DISORDER ; SEROTONIN TRANSPORTER GENOTYPE ; INDEPENDENT SAMPLES ; 5-FACTOR MODEL ; CHECKLIST ; EXPOSURE ; GENETICS ; VICTIMS ; SUPPORT ; TRAUMA
收录类别	SCI
项目简介	This study was supported by the Knowledge Innovation Project of the Chinese Academy of Sciences (No. KSCX2-EW-Q-18), the National Natural Science Foundation of China (No. 31271099 and No. 30900402), the Outstanding Young Investigator Foundation of the Institute of Psychology, Chinese Academy of Sciences, and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
原文出处	http://ac.els-cdn.com/S0165032713000621/1-s2.0-S0165032713000621-main.pdf?_tid=d2f5bf0a-c92c-11e4-8c3b-00000aacb35f&acdnat=1426215688_a309ec32e91bd8f4d3dac4526f6244a7
语种	英语
WOS记录号	WOS:000322762600024
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10738]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
推荐引用方式 GB/T 7714	Wang, Li,Cao, Chengqi,Wang, Richu,et al. PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors[J]. JOURNAL OF AFFECTIVE DISORDERS,2013,150(1):156-159.
APA	Wang, Li,Cao, Chengqi,Wang, Richu,Qing, Yulan,Zhang, Jianxin,&Zhang, Xiang Yang.(2013).PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors.JOURNAL OF AFFECTIVE DISORDERS,150(1),156-159.
MLA	Wang, Li,et al."PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors".JOURNAL OF AFFECTIVE DISORDERS 150.1(2013):156-159.