Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference

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	Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference
	Qi, Keke1,2 ; Wei, Chuguang3 ; Li, Yonghui1 ; Sui, Nan1
刊名	FRONTIERS IN BEHAVIORAL NEUROSCIENCE
	2013
卷号	7
关键词	orexin the nucleus accumbens shell morphine CPP stress-induced reinstatement drug priming-induced reinstatement
ISSN号	1662-5153
通讯作者	Li, YH (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
产权排序	1
英文摘要	Orexins are found to participate in mediating stress-induced drug relapse. However, the neuroanatomical basis that orexin transmission modulates stress induced drug seeking remains unknown. The nucleus accumbens shell (NAcSh), best known for its role in appetitive and negative motivation via dopamine receptors, is likely to be the potential important brain area where the orexin system mediates stress-induced drug relapse since the function of dopamine system in the NAcSh can be regulated by orexin transmission. In the present study, amorphine conditioned place preference (CPP) model was used to determine whether the two types of orexin receptors would be involved into footshock-induced and/or drug priming-induced CPP reinstatement differentially. The results showed that blockade of orexin-1 or orexin-2 receptor in the NAcSh significantly attenuated stress-induced morphine CPP reinstatement, but neither of the orexin antagonists had any effect on morphine priming induced reinstatement. These findings indicate that the NAcSh is a brain area through which orexins participate in stress but not drug priming-induced relapse of opioid seeking.
学科主题	Physiological psychology/Biological Psychology
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Behavioral Sciences ; Neurosciences
研究领域[WOS]	Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]	COCAINE-SEEKING BEHAVIOR ; VENTRAL TEGMENTAL AREA ; MESOLIMBIC DOPAMINE ; RAT-BRAIN ; HYPOTHALAMIC NEUROPEPTIDES ; PREFRONTAL CORTEX ; FEEDING-BEHAVIOR ; SLEEP REGULATION ; REWARD-SEEKING ; NEURONS
收录类别	SCI
项目简介	This study was supported by the Chinese Academy of Sciences (KSCX2-EW-R-12, KSCX2-EW-Q-18), the National Basic Research Program (2009CB522002), the National Natural Science Foundation (31070911, 31170988, 31200770), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
语种	英语
WOS记录号	WOS:000325460700001
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10709]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Core Facil, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Qi, Keke,Wei, Chuguang,Li, Yonghui,et al. Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2013,7.
APA	Qi, Keke,Wei, Chuguang,Li, Yonghui,&Sui, Nan.(2013).Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,7.
MLA	Qi, Keke,et al."Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 7(2013).