BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder

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	BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder
	Chang, Su-Hua1 ; Gao, Lei 1,2; Li, Zhao1,2 ; Zhang, Wei-Na1,2 ; Du, Yang 1,2; Wang, Jing1
刊名	BIOLOGICAL PSYCHIATRY
	2013
卷号	74 期号:10 页码:727-733
关键词	BDgene bipolar disorder data analysis genetic database genetic overlap major depressive disorder schizophrenia
ISSN号	0006-3223
通讯作者	Wang, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
产权排序	1
英文摘要	Background: Bipolar disorder (BD) is a common psychiatric disorder with complex genetic architecture. It shares overlapping genetic influences with schizophrenia (SZ) and major depressive disorder (MDD). Large numbers of genetic studies of BD and cross-disorder studies between BD and SZ/MDD have accumulated numerous genetic data. There is a growing need to integrate the data to provide a comprehensive data set to facilitate the genetic study of BD and its highly relevant diseases. Methods: BDgene database was developed to integrate BD-related genetic factors and shared ones with SZ/MDD from profound literature reading. On the basis of data from the literature, in-depth analyses were performed for further understanding of the data, including gene prioritization, pathway-based analysis, intersection analysis of multidisease candidate genes, and pathway enrichment analysis. Results: BDgene includes multiple types of literature-reported genetic factors of BD with both positive and negative results, including 797 genes, 3119 single nucleotide polymorphisms, and 789 regions. Shared genetic factors such as single nucleotide polymorphisms, genes, and regions from published cross-disorder studies among BD and SZ/MDD were also presented. In-depth data analyses identified 43 BD core genes; 70 BD candidate pathways; and 127, 79, and 107 new potential cross-disorder genes for BD-SZ, BD-MDD, and BD-SZ-MDD, respectively. Conclusions: As a central genetic database for BD and the first cross-disorder database for BD and SZ/MDD, BDgene provides not only a comprehensive review of current genetic research but also high-confidence candidate genes and pathways for understanding of BD mechanism and shared etiology among its relevant diseases. BDgene is freely available at http://bdgene.psych.ac.cn.
学科主题	Abnormal psychology，Health psychology
收录类别	SCI
项目简介	This work was supported by the State Administration of Foreign Experts Affairs of Chinese Academy of Sciences (CAS/SAFEA) International Partnership Program for Creative Research Teams (Grant No. Y2CX131003), the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KSCX2-EW-J-8), and Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. We thank Dr. Kun-Lin Zhang for his valuable suggestions on parameter selection of pathway-based analysis for genome-wide association studies.
原文出处	http://ac.els-cdn.com/S0006322313003867/1-s2.0-S0006322313003867-main.pdf?_tid=d90a1206-a852-11e4-a082-00000aab0f6b&acdnat=1422603631_66a40d35602420b6fad5f6f0e982dd45
语种	英语
WOS记录号	WOS:000325972700012
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10676]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Chang, Su-Hua,Gao, Lei,Li, Zhao,et al. BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder[J]. BIOLOGICAL PSYCHIATRY,2013,74(10):727-733.
APA	Chang, Su-Hua,Gao, Lei,Li, Zhao,Zhang, Wei-Na,Du, Yang,&Wang, Jing.(2013).BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder.BIOLOGICAL PSYCHIATRY,74(10),727-733.
MLA	Chang, Su-Hua,et al."BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder".BIOLOGICAL PSYCHIATRY 74.10(2013):727-733.