Alzheimer's disease-related changes in regional spontaneous brain activity levels and inter-region interactions in the default mode network

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	Alzheimer's disease-related changes in regional spontaneous brain activity levels and inter-region interactions in the default mode network
	Wen, Xuyun 1; Wu, Xia 1,2; Li, Rui3 ; Fleisher, Adam S.4,5; Reiman, Eric M.4,6,7; Wen, Xiaotong 8; Chen, Kewei 4; Yao, Li 1,2
刊名	BRAIN RESEARCH
	2013
卷号	1509 页码:58-65
关键词	Alzheimer's disease (AD) Default mode network (DMN) Granger causality Power Medial prefrontal cortex
ISSN号	0006-8993
通讯作者	Wu, X (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Wai St 19, Beijing 100875, Peoples R China.
产权排序	3
英文摘要	The degree of Granger causal modeling estimated influence for a brain region was reported to predict its blood oxygenation level-dependent (BOLD) activity level in the resting-state default mode network (DMN). Many brain disorders, such as Alzheimer's disease (AD), may alter the influence strength, activity levels, or both. Whether the relationship or prediction between these two will be affected under disease condition is unknown. In this study, the spontaneous brain activity, and inter-regional Granger causality connection were investigated over eight core DMN regions in AD patients in contrast to that in normal controls. Compared to normal control (NC), AD patients had both decreased BOLD activity level and Granger causal influence in medial prefrontal cortex and decreased activity level in inferior parietal cortex showed. However, the positive correlation between the BOLD activity level and the degree of the Granger causal modeling defined influence was found not altered by AD. (C) 2013 Elsevier B.V. All rights reserved.
学科主题	Physiological psychology/Biological Psychology，Psychology of old age
收录类别	SCI
项目简介	This work was supported by the Fundamental Research Funds for the Central Universities National Key Basic Research Program of China (973 Program) (2012CB720704), the Key Program of National Natural Science Foundation of China (6121001), General Program of National Natural Science Foundation of China (61222113) and Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences (grant Y1CX251005) and the program of State Key Laboratory of Cognitive Neuroscience and Learning (CNLYB1216).
原文出处	http://ac.els-cdn.com/S0006899313003880/1-s2.0-S0006899313003880-main.pdf?_tid=140cbf2a-a5d3-11e4-83b0-00000aacb361&acdnat=1422328852_5eee0699c6c63671b4afe9467dab27da
语种	英语
WOS记录号	WOS:000319093400006
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10641]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 2.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing 100875, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Banner Alzheimers Inst, Arizona Alzheimers Consortium, Phoenix, AZ USA 5.Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA 6.Univ Arizona, Coll Med, Dept Psychiat, Phoenix, AZ USA 7.Translat Genom Res Inst, Neurogenom Div, Phoenix, AZ USA 8.Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL USA
推荐引用方式 GB/T 7714	Wen, Xuyun,Wu, Xia,Li, Rui,et al. Alzheimer's disease-related changes in regional spontaneous brain activity levels and inter-region interactions in the default mode network[J]. BRAIN RESEARCH,2013,1509:58-65.
APA	Wen, Xuyun.,Wu, Xia.,Li, Rui.,Fleisher, Adam S..,Reiman, Eric M..,...&Yao, Li.(2013).Alzheimer's disease-related changes in regional spontaneous brain activity levels and inter-region interactions in the default mode network.BRAIN RESEARCH,1509,58-65.
MLA	Wen, Xuyun,et al."Alzheimer's disease-related changes in regional spontaneous brain activity levels and inter-region interactions in the default mode network".BRAIN RESEARCH 1509(2013):58-65.