Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats

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	Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats
	Gao, Jun; Li, Yonghui; Zhu, Ning; Brimijoin, Stephen; Sui, Nan
刊名	JOURNAL OF PSYCHOPHARMACOLOGY
	2013
卷号	27 期号:2 页码:181-191
关键词	Abstinence D1-like D2-like dorsolateral caudate-putamen (dlCPu) morphine nucleus accumbens shell (NAshell) seeking self-administration
ISSN号	0090-6905
通讯作者	Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
产权排序	1
英文摘要	Drug-associated cues can elicit relapse to drug seeking after abstinence. Studies with extinction-reinstatement models implicate dopamine (DA) in the nucleus accumbens shell (NAshell) and dorsolateral caudate-putamen (dlCPu) in cocaine seeking. However, less is known about their roles in cue-induced opiate seeking after prolonged abstinence. Using a morphine self-administration and abstinence-relapse model, we explored the roles of NAshell and dlCPu DA and the D1/D2-like receptor mechanisms underlying morphine rewarding and/or seeking. Acquisition of morphine self-administration was examined following 6-Hydroxydopamine hydrobromide (6-OHDA) lesions of the NAshell and dlCPu. For morphine seeking, rats underwent 3 weeks' morphine self-administration followed by 3 weeks' abstinence from morphine and the training environment. Prior to testing, 6-OHDA, D1 antagonist SCH23390, or D2 antagonist eticlopride was locally injected; then rats were exposed to morphine-associated contextual and discrete cues. Results show that acquisition of morphine self-administration was inhibited by NAshell (not dlCPu) lesions, while morphine seeking was attenuated by lesions of either region, by D1 (not D2) receptor blockade in NAshell, or by blockade of either D1 or D2 receptors in dlCPu. These data indicate a critical role of dopaminergic transmission in the NAshell (via D1-like receptors) and dlCPu (via D1- and D2-like receptors) in morphine seeking after prolonged abstinence.
学科主题	Cognitive neuroscience
收录类别	SCI
项目简介	This work was supported by the National Basic Research Program of China (2009CB522002); Knowledge Innovation Program of Chinese Academy of Sciences (KSCX2-EW-R-12); National Natural Science Foundation Grants of China (31170988); and Chinese Academy of Sciences Visiting Professorships for Senior International Scientists Program (2010T1S13).
原文出处	http://ac.els-cdn.com/S0924977X11000022/1-s2.0-S0924977X11000022-main.pdf?_tid=e31ba62a-ce08-11e4-ae03-00000aab0f26&acdnat=1426750009_92476d403c6c642882fee8bdd1b4b7ea
语种	英语
WOS记录号	WOS:000313900200008
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10626]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
推荐引用方式 GB/T 7714	Gao, Jun,Li, Yonghui,Zhu, Ning,et al. Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2013,27(2):181-191.
APA	Gao, Jun,Li, Yonghui,Zhu, Ning,Brimijoin, Stephen,&Sui, Nan.(2013).Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats.JOURNAL OF PSYCHOPHARMACOLOGY,27(2),181-191.
MLA	Gao, Jun,et al."Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats".JOURNAL OF PSYCHOPHARMACOLOGY 27.2(2013):181-191.