Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors | |
Chen, Long1,2; Lui, Su1; Wu, Qi-Zhu1; Zhang, Wei2; Zhou, Dong2; Chen, Hua-Fu3; Huang, Xiao-Qi1; Kuang, Wei-Hong2; Chan, Raymond C.4; Mechelli, Andrea5 | |
刊名 | HUMAN BRAIN MAPPING |
2013 | |
卷号 | 34期号:2页码:367-373 |
关键词 | stress depression PTSD earthquake MRI diffusion tensor imaging |
ISSN号 | 1065-9471 |
通讯作者 | Gong, QY (reprint author), Sichuan Univ, W China Hosp, Dept Radiol, Ctr Diagnost Imaging,HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China. |
产权排序 | 4 |
英文摘要 | A characterization of the impact of natural disasters on the brain of survivors is critical for a better understanding of posttraumatic responses and may inform the development of more effective early interventions. Here we report alterations in white matter microstructure in survivors soon after Wenchuan earthquake in China in 2008. Within 25 days after the Wenchuan earthquake, 44 healthy survivors were recruited and scanned on a 3T MR imaging system. The survivors were divided into two groups according to their self-rating anxiety scale (SAS) score, including the SAS(+) (SAS > 55 after correction) group and SAS(-) (SAS < 55 after correction) group. Thrity-two healthy volunteers were also recruited as control group before earthquake. Individual maps of fractional anisotropy (FA) were calculated and voxel-based analysis (VBA) was performed to allow the comparison between survivors and controls using ANCOVAs in SPM2. In addition, a correlation between SAS score and regional FA value was examined using Pearson's correlation analysis in SPSS 11.5. Compared with the healthy cohort, the whole group of 44 survivors showed significantly decreased FA values in the right prefrontal lobe, the parietal lobe, the basal ganglia, and the right parahippocampus. These effects did not appear to depend on self-rating anxiety. For the first time we provide evidence that acute trauma altered cerebral microstructure within the limbic system; furthermore, these alterations are evident shortly after the traumatic event, highlighting the need for early evaluation and intervention for trauma survivors. Hum Brain Mapp, 2013. (C) 2011 Wiley Periodicals, Inc. |
学科主题 | Trauma psychology, |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
关键词[WOS] | WHITE-MATTER ; NEUROIMAGING EVIDENCE ; DISORDER ; ARCHITECTURE ; ACTIVATION ; DEPRESSION ; IMAGES ; MEMORY ; PTSD |
收录类别 | SCI |
项目简介 | Contract grant sponsor: National Basic Research Program of China; Contract grant numbers: 973 Program 2007CB512305/2; Contract grant sponsor: National Natural Science Foundation; Contract grant numbers: 81030027 and 30900361; Contract grant sponsor: the Distinguished Young Scholars of Sichuan; Contract grant numbers: 2011JQ0005; Contract grant sponsor: the Programs for New Century Excellent Talents in University; Contract grant numbers: NCET-10-0596; Dr QY Gong also acknowledges the support from the American CMB Distinguished Professorship Award administered by the Institute of International Education, USA. |
原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/hbm.21438/epdf |
语种 | 英语 |
WOS记录号 | WOS:000313115000010 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/10846] |
专题 | 心理研究所_脑与认知科学国家重点实验室 |
作者单位 | 1.Sichuan Univ, W China Hosp, Dept Radiol, Ctr Diagnost Imaging,HMRRC, Chengdu 610041, Peoples R China 2.Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Dept Neurol & Psychiat, Chengdu 610041, Peoples R China 3.Univ Elect Sci & Technol China, Sch Sci & Technol, Brain Funct Lab, Chengdu 610054, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 5.Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London WC2R 2LS, England |
推荐引用方式 GB/T 7714 | Chen, Long,Lui, Su,Wu, Qi-Zhu,et al. Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors[J]. HUMAN BRAIN MAPPING,2013,34(2):367-373. |
APA | Chen, Long.,Lui, Su.,Wu, Qi-Zhu.,Zhang, Wei.,Zhou, Dong.,...&Gong, Qi-Yong.(2013).Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors.HUMAN BRAIN MAPPING,34(2),367-373. |
MLA | Chen, Long,et al."Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors".HUMAN BRAIN MAPPING 34.2(2013):367-373. |
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