Protective effect of sulfated chitosan of C3 sulfation on glycerol-induced acute renal failure in rat kidney

	Protective effect of sulfated chitosan of C3 sulfation on glycerol-induced acute renal failure in rat kidney
	Xing, Ronge; Liu, Song; Yu, Huahua; Qin, Yukun; Chen, Xiaolin; Li, Kecheng; Li, Pengcheng
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2014-04-01
卷号	65 页码:383-388
关键词	Acute renal failure Sulfated chitosan of C3 sulfation (TCTS) Protective effect
通讯作者	Li, PC (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
英文摘要	The purpose of this study was to investigate the protective effects of sulfated chitosan of C3 sulfation (TCTS) on the glycerol-induced acute renal failure. Compared with the normal group, rats from model group exhibited collecting duct and medullary ascending limb dilation and casts by glycerol treating. TCTS, which was injected to pretreat rats by glycerol, exerted a protective effect. The results showed that serum creatinine and blood urea nitrogen were markedly increased in glycerol-treated rats. It is proved that TCTS reduced their levels significantly. Ions level in plasma and urine were significantly changed in glycerol-treated rats, whereas TCTS almost recovered their levels back to normal. For female rats, administration of TCTS reduced their mortality. This study showed a noticeable renal morphologic and functional protection by TCTS in glycerol-induced acute renal failure. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology
收录类别	SCI
语种	英语
WOS记录号	WOS:000334092900052
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/24239]
专题	海洋研究所_海洋生物技术研发中心海洋研究所_海洋环境工程技术研究发展中心
作者单位	Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Xing, Ronge,Liu, Song,Yu, Huahua,et al. Protective effect of sulfated chitosan of C3 sulfation on glycerol-induced acute renal failure in rat kidney[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2014,65:383-388.
APA	Xing, Ronge.,Liu, Song.,Yu, Huahua.,Qin, Yukun.,Chen, Xiaolin.,...&Li, Pengcheng.(2014).Protective effect of sulfated chitosan of C3 sulfation on glycerol-induced acute renal failure in rat kidney.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,65,383-388.
MLA	Xing, Ronge,et al."Protective effect of sulfated chitosan of C3 sulfation on glycerol-induced acute renal failure in rat kidney".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 65(2014):383-388.