In Vitro Studies on Regulation of Osteogenic Activities by Electrical Stimulus on Biodegradable Electroactive Polyelectrolyte Multilayers

	In Vitro Studies on Regulation of Osteogenic Activities by Electrical Stimulus on Biodegradable Electroactive Polyelectrolyte Multilayers
	Cui, Haitao ; Wang, Yu ; Cui, Liguo ; Zhang,Peibiao ; Wang,Xianhong ; Wei,Yen ; Chen,Xuesi
刊名	biomacromolecules
	2014
卷号	15 期号:8 页码:3146-3157
关键词	PERCUTANEOUS INTRAMUSCULAR ELECTRODES MESENCHYMAL STROMAL CELLS TISSUE REGENERATION MYOBLAST DIFFERENTIATION BIOMEDICAL APPLICATIONS EXPONENTIAL-GROWTH CONDUCTING POLYMER CARBON NANOTUBES HUMAN MSCS STIMULATION
通讯作者	wei,y
英文摘要	in this study, a novel electroactive tetreaniline-containing degradable polyelectrolyte multilayer film (pem) coating [(poly(l-glutamic acid)-graft-tetreaniline/poly(l-lysine)-graft-tetreaniline)(n), (pga-g-ta/pll-g-ta)(n)] was designed and fabricated by layer-by-layer (lbl) assembly method. compared with the nongrafted pems, the tetreaniline-grafted pems showed higher roughness and stiffness in micro/nanoscale structures. the special surface characteristics and the typical electroconductive properties were more beneficial for adhesion, proliferation, and differentiation of preosteoblast mc3t3-e1 cells. moreover, the enhanced effects were observed on the modulation of mc3t3-e1 cells that differentiated into maturing osteoblasts, when the electroactive pems were coupled with electrical stimulus (es), especially in the early phase of the osteoblast differentiation. the alkaline phosphatase (alp) activity, calcium deposition, immunofluorescence staining, and rt-qpcr were evaluated on the differentiation of preosteoblast. these data indicate that the comprehensive effects through coupling electroactive scaffolds with electrical stimulus are better to develop bioelectric strategies to control cell functions for bone regeneration.
收录类别	SCI
语种	英语
WOS记录号	WOS:000340348600035
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/52397]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Cui, Haitao,Wang, Yu,Cui, Liguo,et al. In Vitro Studies on Regulation of Osteogenic Activities by Electrical Stimulus on Biodegradable Electroactive Polyelectrolyte Multilayers[J]. biomacromolecules,2014,15(8):3146-3157.
APA	Cui, Haitao.,Wang, Yu.,Cui, Liguo.,Zhang,Peibiao.,Wang,Xianhong.,...&Chen,Xuesi.(2014).In Vitro Studies on Regulation of Osteogenic Activities by Electrical Stimulus on Biodegradable Electroactive Polyelectrolyte Multilayers.biomacromolecules,15(8),3146-3157.
MLA	Cui, Haitao,et al."In Vitro Studies on Regulation of Osteogenic Activities by Electrical Stimulus on Biodegradable Electroactive Polyelectrolyte Multilayers".biomacromolecules 15.8(2014):3146-3157.