Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro | |
Zhang, He1; Fei, Jinbo1; Yan, Xuehai2; Wang, Anhe3; Li, Junbai1 | |
刊名 | ADVANCED FUNCTIONAL MATERIALS
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2015-02-25 | |
卷号 | 25期号:8页码:1193-1204 |
关键词 | DRUG-DELIVERY SYSTEMS PEPTIDE NANOTUBES ANTICANCER DRUG SUPRAMOLECULAR HYDROGELS PH TEMPERATURE NANOWIRES POLYSACCHARIDE RESISTANCE MICELLES |
ISSN号 | 1616-301X |
其他题名 | Adv. Funct. Mater. |
中文摘要 | Small aldehyde molecule are demonstrated to induce cationic diphenylalanine to assemble into monodisperse enzyme-responsive nanocarriers with high biocompatibility and excellent biodegradability. The formation of Schiff base covalent bond and accompanying pi-pi interaction of aromatic rings are found to be the mainly driving forces for the assembly of the nanocarriers. Interestingly, the nanocarriers show autofluorescence due to the n-pi* transitions of C = N bonds, which lends them visually traceable property in living cells. Importantly, the nanocarriers can be taken in by cells and biodegraded in the cells. In addition, doxorubicin is easily loaded into the nanocarriers with high encapsulation amount, and its release can be triggered by tyrisin under physiological conditions. Noticeably, even at a very low drug concentration, the doxorubicin-loaded nanocarriers still exhibit a much higher killing capacity of HeLa cells in vitro, compared to the equivalent-dose free doxorubicin, indicating they have a great potential biomedical application. |
英文摘要 | Small aldehyde molecule are demonstrated to induce cationic diphenylalanine to assemble into monodisperse enzyme-responsive nanocarriers with high biocompatibility and excellent biodegradability. The formation of Schiff base covalent bond and accompanying pi-pi interaction of aromatic rings are found to be the mainly driving forces for the assembly of the nanocarriers. Interestingly, the nanocarriers show autofluorescence due to the n-pi* transitions of C = N bonds, which lends them visually traceable property in living cells. Importantly, the nanocarriers can be taken in by cells and biodegraded in the cells. In addition, doxorubicin is easily loaded into the nanocarriers with high encapsulation amount, and its release can be triggered by tyrisin under physiological conditions. Noticeably, even at a very low drug concentration, the doxorubicin-loaded nanocarriers still exhibit a much higher killing capacity of HeLa cells in vitro, compared to the equivalent-dose free doxorubicin, indicating they have a great potential biomedical application. |
WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
关键词[WOS] | DRUG-DELIVERY SYSTEMS ; PEPTIDE NANOTUBES ; ANTICANCER DRUG ; SUPRAMOLECULAR HYDROGELS ; PH ; TEMPERATURE ; NANOWIRES ; POLYSACCHARIDE ; RESISTANCE ; MICELLES |
收录类别 | SCI |
原文出处 | |
语种 | 英语 |
WOS记录号 | WOS:000349817200003 |
公开日期 | 2015-04-01 |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/11889] ![]() |
专题 | 过程工程研究所_研究所(批量导入) |
作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, He,Fei, Jinbo,Yan, Xuehai,et al. Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(8):1193-1204. |
APA | Zhang, He,Fei, Jinbo,Yan, Xuehai,Wang, Anhe,&Li, Junbai.(2015).Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro.ADVANCED FUNCTIONAL MATERIALS,25(8),1193-1204. |
MLA | Zhang, He,et al."Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro".ADVANCED FUNCTIONAL MATERIALS 25.8(2015):1193-1204. |
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