Characterization and Identification of the Chemical Compositions in a Traditional Uighur Medicine Prescription Yizhihao Granule by LC-ESI-QTOF-MS

CORC > 新疆理化技术研究所 > 中国科学院新疆理化技术研究所 > 省部共建新疆特有药用资源利用重点实验室

	Characterization and Identification of the Chemical Compositions in a Traditional Uighur Medicine Prescription Yizhihao Granule by LC-ESI-QTOF-MS
	Gu, DY (Gu, Dongyu); Yang, Y (Yang, Yi); Hang, B (Hang, Ba); Lv, QY (Lv, Qiaoying); Aisa, HA (Aisa, Haji Akber
刊名	JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
	2015
卷号	38 期号:2 页码:229-242
关键词	traditional Uighur medicinal prescription Yizhihao granule fragmentation pathways chemical compositions LC-QTOF-MS/MS characterization and identification
ISSN号	1082-6076
通讯作者	Aisa, HA
中文摘要	An efficient method was developed and established for the rapid analysis of a traditional Uighur medicinal prescription, Yizhihao granule, by liquid chromatography-Quadrupole time-of-flight tandem mass spectrometry. HPLC was performed with a Poroshell 120-EC18 column with 2.7 mu m particle size using A gradient elution system. A quadrupole time-of-flight analyzer was used for the determination of accurate mass of the protonated or deprotonated molecules and fragment ions. Sixty-six constituents including amino acids, organic acids (aliphatic acids, benzoic acid derivatives, and chlorogenic acids), alkaloids (indole and quinazolinone type), flavonoids (C,O-glycoside, C-glycosides, O-glycosides, and aglycone), sesquiterpenoids (rupestonic acid derivatives), and other compounds were identified or tentatively characterized in Yizhihao granule as a presented application of prescription according to the accurate mass, MS/MS data, and relevant literature. Additionally, the fragmentation pathways of two rupestonic acid derivatives were proposed. The relationship between structure features and fragmentation patterns were investigated thoroughly and applied in the on-line analysis to deduce the composition of traditional Uighur herbal prescription. The present method and results should be beneficial in the development of traditional Uighur herbal prescription.
收录类别	SCI
资助信息	National Basic Research Program of China；West Light Foundation of The Chinese Academy of Sciences；National Natural Science Foundation of China；China National Funds for Distinguished Young Scientists
公开日期	2015-03-11
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/4208]
专题	新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室新疆理化技术研究所_资源化学研究室
作者单位	Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China;Dalian Ocean Univ, Sch Marine Sci & Environm Engn, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Gu, DY ,Yang, Y ,Hang, B ,et al. Characterization and Identification of the Chemical Compositions in a Traditional Uighur Medicine Prescription Yizhihao Granule by LC-ESI-QTOF-MS[J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,2015,38(2):229-242.
APA	Gu, DY ,Yang, Y ,Hang, B ,Lv, QY ,&Aisa, HA .(2015).Characterization and Identification of the Chemical Compositions in a Traditional Uighur Medicine Prescription Yizhihao Granule by LC-ESI-QTOF-MS.JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,38(2),229-242.
MLA	Gu, DY ,et al."Characterization and Identification of the Chemical Compositions in a Traditional Uighur Medicine Prescription Yizhihao Granule by LC-ESI-QTOF-MS".JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES 38.2(2015):229-242.