Developmental Reduction of Asynchronous GABA Release from Neocortical Fast-Spiking Neurons

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	Developmental Reduction of Asynchronous GABA Release from Neocortical Fast-Spiking Neurons
	Jiang, Man; Yang, Mingpo; Yin, Luping; Zhang, Xiaohui; Shu, Yousheng
刊名	CEREBRAL CORTEX
	2015
卷号	25 期号:1 页码:258-270
关键词	MOUSE VISUAL-CORTEX PARVALBUMIN-POSITIVE INTERNEURONS CRITICAL PERIOD SYNAPTIC-TRANSMISSION NEUROTRANSMITTER RELEASE POSTNATAL DIFFERENTIATION DEPENDENT PLASTICITY TRANSMITTER RELEASE HIPPOCAMPAL-NEURONS GABAERGIC SYNAPSES
通讯作者	Shu, YS (reprint author), 320 Yueyang Rd, Shanghai 200031, Peoples R China.
英文摘要	Delayed asynchronous release (AR) evoked by bursts of presynaptic action potentials (APs) occurs in certain types of hippocampal and neocortical inhibitory interneurons. Previous studies showed that AR provides long-lasting inhibition and desynchronizes the activity in postsynaptic cells. However, whether AR undergoes developmental change remains unknown. In this study, we performed whole-cell recording from fast-spiking (FS) interneurons and pyramidal cells (PCs) in prefrontal cortical slices obtained from juvenile and adult rats. In response to AP trains in FS neurons, AR occurred at their output synapses during both age periods, including FS autapses and FS-PC synapses; however, the AR strength was significantly weaker in adults than that in juveniles. Further experiments suggested that the reduction of AR in adult animals could be attributable to the rapid clearance of residual Ca2+ from presynaptic terminals. Together, our results revealed that the AR strength was stronger at juvenile but weaker in adult, possibly resulting from changes in presynaptic Ca2+ dynamics. AR changes may meet the needs of the neural network to generate different types of oscillations for cortical processing at distinct behavioral states.
学科主题	Neurosciences
WOS标题词	Neurosciences & Neurology
收录类别	SCI
语种	英语
WOS记录号	WOS:000347417600024
公开日期	2015-05-27
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2672]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Jiang, Man,Yang, Mingpo,Yin, Luping,et al. Developmental Reduction of Asynchronous GABA Release from Neocortical Fast-Spiking Neurons[J]. CEREBRAL CORTEX,2015,25(1):258-270.
APA	Jiang, Man,Yang, Mingpo,Yin, Luping,Zhang, Xiaohui,&Shu, Yousheng.(2015).Developmental Reduction of Asynchronous GABA Release from Neocortical Fast-Spiking Neurons.CEREBRAL CORTEX,25(1),258-270.
MLA	Jiang, Man,et al."Developmental Reduction of Asynchronous GABA Release from Neocortical Fast-Spiking Neurons".CEREBRAL CORTEX 25.1(2015):258-270.