Local conformation transitions of linear DNA induced by cisplatin

CORC > 物理研究所 > 物理所公开发表论文 > 期刊论文

	Local conformation transitions of linear DNA induced by cisplatin
	Ji, C ; Zhang, LY ; Dou, SX ; Wang, PY
刊名	CHINESE SCIENCE BULLETIN
	2014
卷号	59 期号:25 页码:3085
关键词	Atomic force microscopy Cisplatin DNA Conformation transition
ISSN号	1001-6538
通讯作者	Wang, PY (reprint author), Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Key Lab Soft Matter Phys, Beijing 100190, Peoples R China.
中文摘要	Cisplatin is the most successful anti-tumor drug, and its pharmacological property is generally considered to derive from the modification of DNA molecules. Structural modifications of short DNA induced by cisplatin have already been investigated. However, the conformation transitions induced by cisplatin are not clear. In the present letter, we have studied the effect of low-concentration cisplatin on DNA conformation by using AFM imaging. We observed formations of micro-rod structures of linear DNA induced by cisplatin. A method is presented to quantitatively analyze the occurrence of micro-rod structures. We found that the formation of micro-rod structures depends on the DNA sequence. Based on the results, we proposed a physical mechanism to explain the local conformation transitions of DNA molecules under the influence of cisplatin.
资助信息	National Natural Science Foundation of China [11274374]; National Basic Research Program of China [2009CB930704]
语种	英语
公开日期	2015-04-14
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/59046]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Ji, C,Zhang, LY,Dou, SX,et al. Local conformation transitions of linear DNA induced by cisplatin[J]. CHINESE SCIENCE BULLETIN,2014,59(25):3085.
APA	Ji, C,Zhang, LY,Dou, SX,&Wang, PY.(2014).Local conformation transitions of linear DNA induced by cisplatin.CHINESE SCIENCE BULLETIN,59(25),3085.
MLA	Ji, C,et al."Local conformation transitions of linear DNA induced by cisplatin".CHINESE SCIENCE BULLETIN 59.25(2014):3085.