Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile

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	Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile
	Yang, S ; Yin, XZ ; Wang, CF ; Li, HY ; He, Y ; Xiao, TQ ; Sun, LX ; Li, JS ; York, P ; He, J ; Zhang, JW
刊名	AAPS JOURNAL
	2014
卷号	16 期号:4 页码:860—871
关键词	MULTIPARTICULATE SYSTEMS MECHANISM INTERPRETATION SURFACE-AREA SOLUBLE DRUG KINETICS MICROSPHERES FUNDAMENTALS FORMULATION ADSORPTION SIMULATION
ISSN号	1550-7416
通讯作者	lijiasheng@wanhe-phar.com ; P.York@Bradford.ac.uk ; hejun1016@163.com ; jwzhang@mail.shcnc.ac.cn
英文摘要	Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron radiation X-ray computed microtomography (SR-mu CT) and a sensitive LC/MS/MS method. The purpose of this article is to introduce a powerful, non-invasive and quantitative technique for studying individual pellet microstructures and to investigate the relationship between the microstructure and drug release from single pellets. The data from the single pellet dissolution measurements demonstrated that the release profile of capsules containing approximately 1,000 pellets per unit dose was the summation of the release profiles of the individual pellets. The release profiles of single tamsulosin hydrochloride (TSH) pellets formed three groups when a cluster analysis was performed, and the dissolution rate of the individual pellets correlated well with the combined effects of the drug loading, volume and surface area of the pellets (R (2) = 0.9429). In addition, the void microstructures within the pellet were critical during drug release. Therefore, SR-mu CT is a powerful tool for quantitatively elucidating the three-dimensional microstructure of the individual pellets; because the microstructure controls drug release, it is an important parameter in the quality control of multi-pellet formulations.
收录类别	SCI
语种	英语
WOS记录号	WOS:000338337400023
公开日期	2015-03-13
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/14362]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Yang, S,Yin, XZ,Wang, CF,et al. Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile[J]. AAPS JOURNAL,2014,16(4):860—871.
APA	Yang, S.,Yin, XZ.,Wang, CF.,Li, HY.,He, Y.,...&Zhang, JW.(2014).Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile.AAPS JOURNAL,16(4),860—871.
MLA	Yang, S,et al."Release Behaviour of Single Pellets and Internal Fine 3D Structural Features Co-define the In Vitro Drug Release Profile".AAPS JOURNAL 16.4(2014):860—871.