Rapid detection of multiple class pharmaceuticals in both municipal wastewater and sludge with ultra high performance liquid chromatography tandem mass spectrometry

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境水质学国家重点实验室

	Rapid detection of multiple class pharmaceuticals in both municipal wastewater and sludge with ultra high performance liquid chromatography tandem mass spectrometry
	Yuan, Xiangjuan ; Qiang, Zhimin ; Ben, Weiwei ; Zhu, Bing ; Liu, Junxin
刊名	JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
	2014
卷号	26 期号:9 页码:1949-1959
关键词	Pharmaceuticals Ultrasonic solvent extraction Solid phase extraction UPLC-MS/MS Municipal wastewater Sludge
ISSN号	1001-0742
中文摘要	This work described the development, optimization and validation of an analytical method for rapid detection of multiple-class pharmaceuticals in both municipal wastewater and sludge samples based on ultrasonic solvent extraction, solid-phase extraction, and ultra high performance liquid chromatography-tandem mass spectrometry quantification. The results indicated that the developed method could effectively extract all the target pharmaceuticals (25) in a single process and analyze them within 24 min. The recoveries of the target pharmaceuticals were in the range of 69%-131% for wastewater and 54%-130% for sludge at different spiked concentration levels. The method quantification limits in wastewater and sludge ranged from 0.02 to 0.73 ng/L and from 0.02 to 1.00 mu g/kg, respectively. Subsequently, this method was validated and applied for residual pharmaceutical analysis in a wastewater treatment plant located in Beijing, China. All the target pharmaceuticals were detected in the influent samples with concentrations varying from 0.09 ng/L (tiamulin) to 15.24 mu g/L (caffeine); meanwhile, up to 23 pharmaceuticals were detected in sludge samples with concentrations varying from 60 ng/kg (sulfamethizole) to 8.55 mg/kg (ofloxacin). The developed method demonstrated its selectivity, sensitivity, and reliability for detecting multiple-class pharmaceuticals in complex matrices such as municipal wastewater and sludge. (C) 2014 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
WOS记录号	WOS:000341739600025
公开日期	2015-03-26
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/9592]
专题	生态环境研究中心_环境水质学国家重点实验室
推荐引用方式 GB/T 7714	Yuan, Xiangjuan,Qiang, Zhimin,Ben, Weiwei,et al. Rapid detection of multiple class pharmaceuticals in both municipal wastewater and sludge with ultra high performance liquid chromatography tandem mass spectrometry[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2014,26(9):1949-1959.
APA	Yuan, Xiangjuan,Qiang, Zhimin,Ben, Weiwei,Zhu, Bing,&Liu, Junxin.(2014).Rapid detection of multiple class pharmaceuticals in both municipal wastewater and sludge with ultra high performance liquid chromatography tandem mass spectrometry.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,26(9),1949-1959.
MLA	Yuan, Xiangjuan,et al."Rapid detection of multiple class pharmaceuticals in both municipal wastewater and sludge with ultra high performance liquid chromatography tandem mass spectrometry".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 26.9(2014):1949-1959.