Photoelectrochemical Sensors for the Detection of DNA Damage

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Photoelectrochemical Sensors for the Detection of DNA Damage
	Wu Yiping ; Guo Lianghong
刊名	PROGRESS IN CHEMISTRY
	2014
卷号	26 期号:1 页码:1-9
关键词	DNA sensor photoelectrochemical detection DNA damage toxicity screening
ISSN号	1005-281X
中文摘要	DNA is a kind of genetic material that encodes the genetic instructions used in the development and functioning of all known living organisms and many viruses. DNA damage occurs frequently in organisms. Some endogenous and exogenous chemicals have been found to induce structural damages to nuclear DNA by base oxidation or modification. If unrepaired, these damaged DNA may lead to gene mutation and even tumor generation. Due to their short response time, high sensitivity, low cost and ease of miniaturization, electrochemical DNA sensors are well qualified for the rapid screening of industrial and environmental chemicals for their potential geno-toxicity. This review article first introduces briefly the types and working mechanisms of current electrochemical DNA sensors. Then it describes in more detail the work on electrochemical and photoelectrochemical sensors for the detection of DNA damage, based largely on the work of our own laboratory, including general type sensors for the rapid screening of industrial and environmental chemicals with potential geno-toxicity,, as well as specific type sensors for the identification and quantification of DNA damage products such as 8-oxodGuo and methylated DNA bases. In the end, the existing problems and future research directions of the DNA damage electrochemical sensors are discussed.
WOS记录号	WOS:000330554500001
公开日期	2015-03-24
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/9425]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Wu Yiping,Guo Lianghong. Photoelectrochemical Sensors for the Detection of DNA Damage[J]. PROGRESS IN CHEMISTRY,2014,26(1):1-9.
APA	Wu Yiping,&Guo Lianghong.(2014).Photoelectrochemical Sensors for the Detection of DNA Damage.PROGRESS IN CHEMISTRY,26(1),1-9.
MLA	Wu Yiping,et al."Photoelectrochemical Sensors for the Detection of DNA Damage".PROGRESS IN CHEMISTRY 26.1(2014):1-9.