PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion
	Wang, Ling ; Wang, Yu ; Liang, Yong ; Li, Jia ; Liu, Yuchen ; Zhang, Jie ; Zhang, Aiqian ; Fu, Jianjie ; Jiang, Guibin
刊名	SCIENTIFIC REPORTS
	2014
卷号	4 期号:1 页码:-
ISSN号	2045-2322
中文摘要	Male BALB/c mice fed with either a regular or high fat diet were exposed to 0, 5 or 20 mg/kg perfluorooctane sulfonate (PFOS) for 14 days. Increased body weight, serum glucose, cholesterol and lipoprotein levels were observed in mice given a high fat diet. However, all PFOS-treated mice got reduced levels of serum lipid and lipoprotein. Decreasing liver glycogen content was also observed, accompanied by reduced serum glucose levels. Histological and ultrastructural examination detected more lipid droplets accumulated in hepatocytes after PFOS exposure. Moreover, transcripitonal activity of lipid metabolism related genes suggests that PFOS toxicity is probably unrelevant to PPAR alpha's transcription. The present study demonstrates a lipid disturbance caused by PFOS and thus point to its role in inhibiting the secretion and normal function of low density lipoproteins.
WOS记录号	WOS:000333797300009
公开日期	2015-03-24
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/9422]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Wang, Ling,Wang, Yu,Liang, Yong,et al. PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion[J]. SCIENTIFIC REPORTS,2014,4(1):-.
APA	Wang, Ling.,Wang, Yu.,Liang, Yong.,Li, Jia.,Liu, Yuchen.,...&Jiang, Guibin.(2014).PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion.SCIENTIFIC REPORTS,4(1),-.
MLA	Wang, Ling,et al."PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion".SCIENTIFIC REPORTS 4.1(2014):-.