Perturbation of physiological systems by nanoparticles

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Perturbation of physiological systems by nanoparticles
	Zhang, Yi ; Bai, Yuhong ; Jia, Jianbo ; Gao, Ningning ; Li, Yang ; Zhang, Ruinan ; Jiang, Guibin ; Yan, Bing
刊名	CHEMICAL SOCIETY REVIEWS
	2014
卷号	43 期号:10 页码:3762-3809
ISSN号	0306-0012
中文摘要	Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.
WOS记录号	WOS:000335014000018
公开日期	2015-03-24
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/9421]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zhang, Yi,Bai, Yuhong,Jia, Jianbo,et al. Perturbation of physiological systems by nanoparticles[J]. CHEMICAL SOCIETY REVIEWS,2014,43(10):3762-3809.
APA	Zhang, Yi.,Bai, Yuhong.,Jia, Jianbo.,Gao, Ningning.,Li, Yang.,...&Yan, Bing.(2014).Perturbation of physiological systems by nanoparticles.CHEMICAL SOCIETY REVIEWS,43(10),3762-3809.
MLA	Zhang, Yi,et al."Perturbation of physiological systems by nanoparticles".CHEMICAL SOCIETY REVIEWS 43.10(2014):3762-3809.