Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer

	Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer
	Lv, Shixian ; Tang, Zhaohui ; Li, Mingqiang ; Lin,Jian ; Song,Wantong ; Liu,Huaiyu ; Huang,Yubin ; Zhang,Yuanyuan ; Chen,Xuesi
刊名	biomaterials
	2014
卷号	35 期号:23 页码:6118-6129
关键词	METASTATIC BREAST-CANCER DRUG-DELIVERY DIBLOCK COPOLYMERS THERAPY NANOPARTICLES COMBINATION NANOCARRIERS CHEMOTHERAPY DOCETAXEL MICELLES
ISSN号	0142-9612
通讯作者	chen,xs
中文摘要	despite progress, combination therapy of different functional drugs to increase the efficiency of anticancer treatment still remains challenges. an amphiphilic methoxy poly(ethylene glycol)-b-poly(l-glutamic acid)-b-poly(l-lysine) triblock copolymer decorated with deoxycholate (mpesg-b-plg-b-pll/doca) was synthesized and developed as a nanovehicle for the co-delivery of anticancer drugs: doxorubicin (dox) and paclitaxel (ptx). the amphiphilic copolymer spontaneously self-assembled into micellar-type nanoparticles in aqueous solutions and the blank nanoparticles possessed excellent stability. three different domains of the copolymer performed distinct functions: peg outer corona provided prolonged circulation, middle biodegradable and hydrophilic plg shell was designed for dox loading through electrostatic interactions, and hydrophobic deoxycholate modified pll served as the container for fix. in vitro cytotoxicity assays against a549 human lung adenocarcinoma cell line demonstrated that the dox + ptx co-delivered nanoparticles (co-nps) exhibited synergistic effect in inducing cancer cell apoptosis. ex vivo dox fluorescence imaging revealed that co-nps had highly efficient targeting and accumulation at the implanted site of a549 xenograft tumor in vivo. co-nps exhibited significantly higher antitumor efficiency in reducing tumor size compared to free drug combination or single drug-loaded nanoparticles, while no obvious side effects were observed during the treatment, indicating this co-delivery system with different functional antitumor drugs provides the clinical potential in cancer therapy.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000337212200014
公开日期	2015-03-25
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50672]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Lv, Shixian,Tang, Zhaohui,Li, Mingqiang,et al. Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer[J]. biomaterials,2014,35(23):6118-6129.
APA	Lv, Shixian.,Tang, Zhaohui.,Li, Mingqiang.,Lin,Jian.,Song,Wantong.,...&Chen,Xuesi.(2014).Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer.biomaterials,35(23),6118-6129.
MLA	Lv, Shixian,et al."Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer".biomaterials 35.23(2014):6118-6129.