A New Quinolizidine Alkaloid from Sophora flavescens

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	A New Quinolizidine Alkaloid from Sophora flavescens
	Wang Lei1,2,3 ; Wu Xing-De 3; He Juan 3; Li Gen-Tao 3; Peng Li-Yan 3; Li Yan3 ; Song Liu-Dong 1,2; Zhao Qin-Shi3
刊名	CHEMISTRY OF NATURAL COMPOUNDS
	2014-11-01
卷号	50 期号:5 页码:876-879
关键词	Sophora flavescens Leguminosae alkaloids cytotoxicity
ISSN号	0009-3130
通讯作者	Wang,L (reprint author),Kunming Med Univ,Sch Pharmaceut Sci,Kunming 650500,Peoples R China. ; ynsld@126.com ; qinshizhao@mail.kib.ac.cn
产权排序	第一
英文摘要	We studied the alkaloid constituents and bioactivity of Sophora flavescens (Leguminosae). The constituents were isolated with silica gel column chromatography, semi-preparative HPLC, Sephadex LH-20, and MPLC packed with MCI gel, and their structures were elucidated on the basis of physical characteristics and spectral data. Compounds 1 and 5-8 were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Ten alkaloids were obtained, and their structures were identified as 17 beta-hydroxysophoridine (1), matrine (2), sophocarpine (3), sophoridine (4), isomatrine (5), 7,11-dehydromatrine (6), mamanine (7), sophoranol (8), oxymatrine (9), and oxysophocarpine (10). Compound 1 is a new alkaloid, and compound 7 was isolated from the Sophora flavescens for the first time. None of the compounds were cytotoxic to five human cancer cell lines.
学科主题	Chemistry, Medicinal;Chemistry, Organic
类目[WOS]	Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Pharmacology & Pharmacy ; Chemistry
关键词[WOS]	LUPIN ALKALOIDS
收录类别	SCI ; IC
资助信息	National Natural Science Foundation of China [21272241, 21172223, 31271579, 81322030]; Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources; Middle Aged Academic Leaders of Kunming, a project from Center of Cooperative Innovation for South China Medicine of Yunnan Province; National Key Basic Research Program of China [2013CB910900]
语种	英语
WOS记录号	WOS:000345139600019
公开日期	2015-01-20
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18460]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China 2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Wang Lei,Wu Xing-De,He Juan,et al. A New Quinolizidine Alkaloid from Sophora flavescens[J]. CHEMISTRY OF NATURAL COMPOUNDS,2014,50(5):876-879.
APA	Wang Lei.,Wu Xing-De.,He Juan.,Li Gen-Tao.,Peng Li-Yan.,...&Zhao Qin-Shi.(2014).A New Quinolizidine Alkaloid from Sophora flavescens.CHEMISTRY OF NATURAL COMPOUNDS,50(5),876-879.
MLA	Wang Lei,et al."A New Quinolizidine Alkaloid from Sophora flavescens".CHEMISTRY OF NATURAL COMPOUNDS 50.5(2014):876-879.