Heterodimeric ent-Kauranoids from Isodon tenuifolius

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	Heterodimeric ent-Kauranoids from Isodon tenuifolius
	Yang, Jian-Hong 1,2; Wang, Wei-Guang 1; Du, Xue 1; He, Fei 1; Zhang, Hai-Bo 1; Li, Xiao-Nian 1; Li, Yan1 ; Pu, Jian-Xin1 ; Sun, Han-Dong1
刊名	JOURNAL OF NATURAL PRODUCTS
	2014-11-01
卷号	77 期号:11 页码:2444-2453
关键词	IMMUNOSUPPRESSIVE POLYKETIDES 5-AMINOLEVULINIC ACID ASSAY marine-associated fungus Daldinia eschscholzii secondary metabolites hydrolysis GC analysis X-ray diffraction analysis
ISSN号	0163-3864
通讯作者	Pu,JX (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Peoples R China. ; pujianxin@mail.kib.ac.cn
产权排序	第一
英文摘要	Thirteen new heterodimeric ent-kauranoids, bistenuifolins A-M (1-13), were isolated from the aerial parts of Isodon tenuifolius. The constituent units of compounds 1-6 were linked by a six-membered dihydropyran ring, while those of compounds 7-11 were joined by a rare single carbon-carbon bond (C-16 -> C-17'). The constituent units of 12 and 13 were linked via an unusual cyclobutane moiety. The structures of these metabolites were established via spectrometric analyses, and the absolute configurations of 1 and 4 were defined by single-crystal X-ray diffraction. Selected compounds were evaluated for their cytotoxicity against a small panel of human tumor cell lines; bistenuifolin B (2) exhibited weak inhibitory effects.
学科主题	Plant Sciences;Chemistry, Medicinal;Pharmacology & Pharmacy
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	DITERPENOIDS ; RUBESCENS ; ABIETANE ; DIMERS
收录类别	SCI ; IC
资助信息	MFLU grant [56101020032]; Mushroom Research Foundation, Chiang Rai, Thailand; Chinese Academy of Sciences [2013T2S0030]; Humidtropics, a CGIAR Research Program; Japan Society for the Promotion of Science (JSPS) [25440199]; Distinguished Scientist Fellowship Program (DSFP), King Saud University, Saudi Arabia
语种	英语
WOS记录号	WOS:000345472100017
公开日期	2015-01-20
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18457]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Yang, Jian-Hong,Wang, Wei-Guang,Du, Xue,et al. Heterodimeric ent-Kauranoids from Isodon tenuifolius[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(11):2444-2453.
APA	Yang, Jian-Hong.,Wang, Wei-Guang.,Du, Xue.,He, Fei.,Zhang, Hai-Bo.,...&Sun, Han-Dong.(2014).Heterodimeric ent-Kauranoids from Isodon tenuifolius.JOURNAL OF NATURAL PRODUCTS,77(11),2444-2453.
MLA	Yang, Jian-Hong,et al."Heterodimeric ent-Kauranoids from Isodon tenuifolius".JOURNAL OF NATURAL PRODUCTS 77.11(2014):2444-2453.