Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway

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	Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway
	Lu, Fu-I 1,2; Sun, Yong-Hua 3,4; Wei, Chang-Yong 4,5; Thisse, Christine 1,3; Thisse, Bernard 1,3
刊名	NATURE COMMUNICATIONS
	2014-11-01
卷号	5 期号:-
关键词	BETA-CATENIN ZEBRAFISH WNT8 CO-REPRESSORS SELF-RENEWAL GROUCHO TRANSCRIPTION GENE ACTIVATION MESODERM TCF3
ISSN号	2041-1723
英文摘要	Upon stimulation by Wnt ligands, the canonical Wnt/beta-catenin signalling pathway results in the stabilization of beta-catenin and its translocation into the nucleus to form transcriptionally active complexes with sequence-specific DNA-binding T-cell factor/lymphoid enhancer factor (TCF/LEF) family proteins. In the absence of nuclear beta-catenin, TCF proteins act as transcriptional repressors by binding to Groucho/Transducin-Like Enhancer of split (TLE) proteins that function as co-repressors by interacting with histone deacetylases whose activity leads to the generation of transcriptionally silent chromatin. Here we show that the transcription factor Ladybird homeobox 2 (Lbx2) positively controls the Wnt/beta-catenin signalling pathway in the posterior lateral and ventral mesoderm of the zebrafish embryo at the gastrula stage, by directly interfering with the binding of Groucho/TLE to TCF, thereby preventing formation of transcription repressor complexes. These findings reveal a novel level of regulation of the canonical Wnt/beta-catenin signalling pathway occurring in the nucleus and involving tissue-specific derepression of TCF by Lbx2.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	BETA-CATENIN ; ZEBRAFISH WNT8 ; CO-REPRESSORS ; SELF-RENEWAL ; GROUCHO ; TRANSCRIPTION ; GENE ; ACTIVATION ; MESODERM ; TCF3
收录类别	SCI
语种	英语
WOS记录号	WOS:000345655100008
公开日期	2015-01-20
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/20328]
专题	水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
作者单位	1.Univ Virginia, Dept Cell Biol, Charlottesville, VA 22908 USA 2.Natl Cheng Kung Univ, Inst Biotechnol, Tainan 701, Taiwan 3.Univ Strasbourg, CNRS, INSERM, Inst Genet & Biol Mol & Cellulaire, F-67400 Illkirch Graffenstaden, France 4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lu, Fu-I,Sun, Yong-Hua,Wei, Chang-Yong,et al. Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway[J]. NATURE COMMUNICATIONS,2014,5(-).
APA	Lu, Fu-I,Sun, Yong-Hua,Wei, Chang-Yong,Thisse, Christine,&Thisse, Bernard.(2014).Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway.NATURE COMMUNICATIONS,5(-).
MLA	Lu, Fu-I,et al."Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway".NATURE COMMUNICATIONS 5.-(2014).