Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase

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	Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase
	[Li, Sumei ; Xiao, Ji ; Zhu, Yiguang ; Zhang, Guangtao ; Yang, Chunfang ; Zhang, Haibo ; Ma, Liang ; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Xiao, Ji] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
刊名	ORGANIC LETTERS
	2013
卷号	15 期号:6 页码:1374-1377
ISSN号	1523-7060
通讯作者	czhang2006@gmail.com
中文摘要	The Identification of a lobophorin biosynthetic gene cluster from the deep-sea derived Streptomyces sp. SCSIO 01127 reveals a paradigm of three glycosyltransferases (GTs) LobG1-LobG3 being responsible for appending four sugars. Characterization of five differentially glycosylated metabolites from three GT gene-inactivation mutants allowed the assignment of GT functions and the implication of LobG3 as an iterative GT to attach two digitoxoses.
学科主题	Chemistry, Organic
资助信息	This work is supported in part by NSFC (31125001), CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, 08SL111002), and MOST (2010CB833805 and 2012AA092104). We are grateful to the analytical facility at SCSIO for recording NMR data.
原文出处	AMER CHEMICAL SOC
语种	英语
WOS记录号	WOS:000316520300056
公开日期	2015-01-22
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/11052]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	[Li, Sumei,Xiao, Ji,Zhu, Yiguang,et al. Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase[J]. ORGANIC LETTERS,2013,15(6):1374-1377.
APA	[Li, Sumei.,Xiao, Ji.,Zhu, Yiguang.,Zhang, Guangtao.,Yang, Chunfang.,...&[Xiao, Ji] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China.(2013).Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase.ORGANIC LETTERS,15(6),1374-1377.
MLA	[Li, Sumei,et al."Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase".ORGANIC LETTERS 15.6(2013):1374-1377.