miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death

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	miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death
	[Guo, Chuanyu ; Yan, Yang ; Huang, Xiaohong ; Qin, Qiwei] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China ; [Guo, Chuanyu] Univ Chinese Acad Sci, Beijing, Peoples R China ; [Cui, Huachun] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
刊名	PLOS ONE
	2013
卷号	8 期号:12 页码:-e83027
ISSN号	1932-6203
通讯作者	qinqw@scsio.ac.cn
中文摘要	Growing evidence demonstrates that various large DNA viruses could encode microRNAs (miRNAs) that regulate host and viral genes to achieve immune evasion. In this study, we report that miR-homoHSV, an miRNA encoded by Singapore grouper iridovirus (SGIV), can attenuate SGIV-induced cell death. Mechanistically, SGIV miR-homoHSV targets SGIV ORF136R, a viral gene that encodes the pro-apoptotic lipopolysaccharide-induced TNF-alpha (LITAF)-like factor. miR-homoHSV suppressed exogenous and endogenous SGIV LITAF expression, and thus inhibited SGIV LITAF-induced apoptosis. Meanwhile, miR-homoHSV expression was able to attenuate cell death induced by viral infection, presumably facilitating viral replication through the down-regulation of the pro-apoptotic gene SGIV LITAF. Together, our data suggest miR-homoHSV may serve as a feedback regulator of cell death during viral infection. The findings of this study provide a better understanding of SGIV replication and pathogenesis.
学科主题	Multidisciplinary Sciences
资助信息	This work was supported by grants from the National Basic Research Program of China (973) (2012CB114402), the National Natural Science Foundation of China (41206137), the Knowledge Innovative Program of the Chinese Academy of Sciences (SQ201116, KZCX2-EW-Q213). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
原文出处	PUBLIC LIBRARY SCIENCE
语种	英语
WOS记录号	WOS:000327947800105
公开日期	2015-01-22
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10947]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	[Guo, Chuanyu,Yan, Yang,Huang, Xiaohong,et al. miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death[J]. PLOS ONE,2013,8(12):-e83027.
APA	[Guo, Chuanyu,Yan, Yang,Huang, Xiaohong,Qin, Qiwei] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China,[Guo, Chuanyu] Univ Chinese Acad Sci, Beijing, Peoples R China,&[Cui, Huachun] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA.(2013).miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death.PLOS ONE,8(12),-e83027.
MLA	[Guo, Chuanyu,et al."miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death".PLOS ONE 8.12(2013):-e83027.