Joint detection of tumor markers with imaging ellipsometry biosensor

	Joint detection of tumor markers with imaging ellipsometry biosensor
	Niu Y(牛宇); Kang TF(康腾飞); Jin G(靳刚)
刊名	Thin Solid Films
	2014-11-28
通讯作者邮箱	gajin@imech.ac.cn
卷号	571 页码:453-462
关键词	Joint detection Tumor markers Biosensor Imaging ellipsometry
ISSN号	0040-6090
通讯作者	Jin, G (reprint author), 15 Bei Si Huan West Rd, Beijing 100190, Peoples R China.
产权排序	[Niu, Yu; Kang, Tengfei; Jin, Gang] Chinese Acad Sci, Inst Mech, NML, Beijing 100190, Peoples R China; [Kang, Tengfei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
合作状况	国内
中文摘要	Tumor marker detection contributes to the early diagnosis of cancers. However, due to the lack of detection specificity, its results cannot act as a direct evidence to confirm cancer occurrence in clinic. Joint detection of tumor markers may improve the detection specificity. As a trial for clinical diagnosis of hepatocellular carcinoma, alpha-fetoprotein, alpha-L-fucosidase and ferritin have been combined and detected with a label-free, phase sensitive and high throughput imaging ellipsometry biosensor (IEB). Eighty-two sera have been quantitatively detected with IEB and the results are in agreement with the clinical standard approaches. Evaluated by receiver operating characteristic analysis, the specificity of joint detection improves remarkably with IEB for hepatocellular carcinoma. It can be foreseen that the joint detection of tumor markers with IEB has a potential for clinical cancer diagnosis. (C) 2014 Elsevier B.V. All rights reserved.
学科主题	Materials Science ; Physics
分类号	二类/Q2
类目[WOS]	Materials Science, Multidisciplinary ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]	Materials Science ; Physics
关键词[WOS]	CANCER ; VISUALIZATION
收录类别	SCI ; EI
原文出处	http://dx.doi.org/10.1016/j.tsf.2014.01.043
语种	英语
WOS记录号	WOS:000346055200021
公开日期	2015-01-23
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/49491]
专题	力学研究所_国家微重力实验室
推荐引用方式 GB/T 7714	Niu Y,Kang TF,Jin G. Joint detection of tumor markers with imaging ellipsometry biosensor[J]. Thin Solid Films,2014,571:453-462.
APA	Niu Y,Kang TF,&Jin G.(2014).Joint detection of tumor markers with imaging ellipsometry biosensor.Thin Solid Films,571,453-462.
MLA	Niu Y,et al."Joint detection of tumor markers with imaging ellipsometry biosensor".Thin Solid Films 571(2014):453-462.