| Chemical constituents from Euphorbia stracheyi and their biological activities | |
Yang, Da-Song1; Peng, Wei-Bing2; Li, Zi-Lei1; Wang, Xue2; Wei, Jian-Guo1; He, Qiu-Xia2; Yang, Yong-Ping1 ; Liu, Ke-Chun2; Li, Xiao-Li1
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| 刊名 | FITOTERAPIA
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| 2014-09-01 | |
| 卷号 | 97页码:211-218 |
| 关键词 | Euphorbia stracheyi Euphorbiaceae Diterpenoid Sesquiterpene Cytotoxicity |
| ISSN号 | 0367-326X |
| 通讯作者 | Li,XL (reprint author),Chinese Acad Sci,Kunming Inst Bot,Inst Tibetan Plateau Res Kunming,Key Lab Econ Plants & Biotechnol,Germplasm Bank W,Kunming 650201,Peoples R China. ; li_xiaoli11@mail.kib.ac.cn |
| 产权排序 | 第一 |
| 英文摘要 | Three new diterpenoids, stracheyioids A-C (1-3), as well as 36 known compounds (4-39) were isolated from the whole plants of Euphorbia stracheyi. Compound 1 was a rare 13-deoxy tigliane diterpenoid and compound 2 was an ingenol diterpenoid characterized by an unique 2Z,4Z-decadienoyl acidic moieties. All the known compounds were isolated from E. stracheyi for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-39 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range 6.64-42.86 mu M. The antiangiogenic activities of the isolated compounds were also evaluated using a zebrafish model. (C) 2014 Elsevier B.V. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | C-13 NMR-SPECTROSCOPY ; PHORBOL ESTERS ; DITERPENES ; GLYCOSIDES ; FISCHERIANA ; DERIVATIVES ; LATHYRANE ; PLANTS ; ROOTS ; OIL |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [31300293, 81202584]; Applied Foundation Research, Yunnan Province [2013FB067]; Basic Research Project of Ministry of Science and Technology of China [2012FY110300]; Major State Basic Research Development Program [2010CB951704] |
| 语种 | 英语 |
| WOS记录号 | WOS:000341346400027 |
| 公开日期 | 2014-11-25 |
| 内容类型 | 期刊论文 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18407]  |
| 专题 | 昆明植物研究所_资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Key Lab Econ Plants & Biotechnol,Germplasm Bank W, Kunming 650201, Peoples R China 2.Shandong Acad Sci, Inst Biol, Jinan 250014, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Da-Song,Peng, Wei-Bing,Li, Zi-Lei,et al. Chemical constituents from Euphorbia stracheyi and their biological activities[J]. FITOTERAPIA,2014,97:211-218. |
| APA | Yang, Da-Song.,Peng, Wei-Bing.,Li, Zi-Lei.,Wang, Xue.,Wei, Jian-Guo.,...&Li, Xiao-Li.(2014).Chemical constituents from Euphorbia stracheyi and their biological activities.FITOTERAPIA,97,211-218. |
| MLA | Yang, Da-Song,et al."Chemical constituents from Euphorbia stracheyi and their biological activities".FITOTERAPIA 97(2014):211-218. |
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