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	Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?
	Wang Y. F. ; Pei L. J. ; Wang J. F. ; Zheng X. Y.
	2012
关键词	methylenetetrahydrofolic acid reductase MTHFR C677T single nucleotide polymorphism ultraviolet radiation spontaneously aborted embryos methylenetetrahydrofolate reductase 5 folate intake risk metaanalysis mutation a1298c 10-methylenetetrahydrofolate reductase
英文摘要	The methylenetetrahydrofolic acid reductase (MTHFR) C677T polymorphism causes an amino-acid change from alanine to valine and results in the enzyme becoming thermolabile and half decreased activity. Its prevalence varies among global population. We collected data about MTHFR C677T polymorphism prevalence from epidemiology studies, as well as ultraviolet (UV) radiations and some other climatological factors from the internet. The results of the correlation and quadric regression showed that there was inverse U-shape relationship between T allele frequency and UV radiation. The explanatory power of UV radiation was stronger than latitude and all climatological factors. Our results supported the hypothesis that the distribution pattern of MTFHR C677T polymorphism in Eurasia might be the result of interaction of genetic and environmental natural selection, especially the UV radiation. Journal of Human Genetics (2012) 57, 780-786; doi:10.1038/jhg.2012.113; published online 20 September 2012
出处	Journal of Human Genetics
卷	57
期	12
页	780-786
收录类别	SCI
语种	英语
ISSN号	1434-5161
内容类型	SCI/SSCI论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/30737]
专题	地理科学与资源研究所_历年回溯文献
推荐引用方式 GB/T 7714	Wang Y. F.,Pei L. J.,Wang J. F.,et al. Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?. 2012.

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