A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 固体润滑国家重点实验室

	A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing
	Fan ZJ(范增杰)1; Liu B(刘斌)2; Wang JQ(王金清)1 ; Zhang SY(张松营)2; Lin QQ(林茜茜)2; Gong PW(公培伟)1 ; Ma LM(马立民)1; Yang SR(杨生荣)1
刊名	Advanced Functional Materials
	2014
卷号	24 期号:25 页码:3933-3943
ISSN号	1616-301X
通讯作者	王金清
英文摘要	Avoiding wound infection and retaining an appropriate level of moisture around woundz are major challenges in wound care management. Therefore, designing hydrogels with desired antibacterial performance and good water-maintaining ability is of particular significance to promote the development of wound dressing. Thus a series of hydrogels are prepared by crosslinking of Ag/graphene composites with acrylic acid and N,N'-methylene bisacrylamide at different mass ratios. The antibacterial performance and accelerated wound-healing ability of hydrogel are systematically evaluated with the aim of attaining a novel and effective wound dressing. The as-prepared hydrogel with the optimal Ag to graphene mass ratio of 5:1 (Ag5G1) exhibits stronger antibacterial abilities than other hydrogels. Meanwhile, Ag5G1 hydrogel exhibits excellent biocompatibility, high swelling ratio, and good extensibility. More importantly, in vivo experiments indicate that Ag5G1 hydrogel can significantly accelerate the healing rate of artificial wounds in rats, and histological examination reveals that it helps to successfully reconstruct intact and thickened epidermis during 15 day of healing of impaired wounds. In one word, the present approach can shed new light on designing of antibacterial material like Ag/graphene composite hydrogel with promising applications in wound dressing.
学科主题	材料科学与物理化学
收录类别	SCI
资助信息	the National Natural Science Foundation of China (Grant Nos. 51205385;51075384);“Top Hundred Talents Program” of Chinese Academy of Sciences
语种	英语
WOS记录号	WOS:000338011200010
公开日期	2014-12-12
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/6961]
专题	兰州化学物理研究所_固体润滑国家重点实验室
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Fan ZJ,Liu B,Wang JQ,et al. A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing[J]. Advanced Functional Materials,2014,24(25):3933-3943.
APA	Fan ZJ.,Liu B.,Wang JQ.,Zhang SY.,Lin QQ.,...&Yang SR.(2014).A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing.Advanced Functional Materials,24(25),3933-3943.
MLA	Fan ZJ,et al."A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing".Advanced Functional Materials 24.25(2014):3933-3943.