Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment

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	Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment
	Liu GQ(刘国强)1,2 ; Cai MR(蔡美荣)1 ; Zhou F(周峰)1 ; Liu WM(刘维民)1
刊名	Journal of Physical Chemistry B
	2014
卷号	118 期号:18 页码:4920-4931
ISSN号	1520-6106
通讯作者	蔡美荣 ; 周峰
英文摘要	The fabrication of core/shell charged polymer brushes-grafted hollow silica nanoparticles (PSPMA-g-HSNPs) is reported. Because of the excellent hydration capability of the shells consisting of charged polymer brushes, the functional nanoparticles can achieve a good lubricating effect in aqueous media via hydration lubrication mechanism. The mesoporous hollow silica cores endow the nanoparticles with drug loading-release capability. Aspirin, as a useful drug for treating arthritis, was employed to carry out in vitro drug loading and release studies. It is clear that brushes-modified hollow silica exhibited long-term drug release performance. The combination of lubrication and drug loading capabilities results in the great clinical potential of new multifunctional nanoparticles as injectable joint lubricant fluid in arthritis treatment.
学科主题	材料科学与物理化学
收录类别	SCI
资助信息	NSFC (21125316;21204095;51335010);973 projects (2013CB632300);Key Research Program of CAS (KJZD-EW-M01)
语种	英语
WOS记录号	WOS:000335878000023
公开日期	2014-12-02
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/6841]
专题	兰州化学物理研究所_固体润滑国家重点实验室
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Liu GQ,Cai MR,Zhou F,et al. Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment[J]. Journal of Physical Chemistry B,2014,118(18):4920-4931.
APA	Liu GQ,Cai MR,Zhou F,&Liu WM.(2014).Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment.Journal of Physical Chemistry B,118(18),4920-4931.
MLA	Liu GQ,et al."Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment".Journal of Physical Chemistry B 118.18(2014):4920-4931.