Relationship between BDE 209 metabolites and thyroid hormone levels in rainbow trout (Oncorhynchus mykiss)

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	Relationship between BDE 209 metabolites and thyroid hormone levels in rainbow trout (Oncorhynchus mykiss)
	Feng, Chenglian ; Xu, Yiping ; Zhao, Gaofeng ; Zha, Jinmiao ; Wu, Fengchang ; Wang, Zijian
刊名	AQUATIC TOXICOLOGY
	2012
卷号	122 页码:28－35
关键词	Decabromodiphenyl ether (BDE 209) Metabolites Thyroid hormone Rainbow trout (Oncorhynchus mykiss)
ISSN号	0166-445X
中文摘要	Decabromodiphenyl ether (BDE 209), the primary component in a commonly used flame retardants, has recently been shown to be metabolized by organisms. In the present study, juvenile rainbow trout (Oncorhynchus mykiss) were exposed to BDE 209 at five nominal gradient concentrations from 50 to 1000 ng/g wet weight for 21 days via a single intraperitoneal injection. Then the liver, kidney and blood samples were collected to analyze for its debrominated, hydroxylated and methoxylated metabolites. The relationships between levels of BDE 209 metabolites in different tissues and thyroid hormone (TH) levels in plasma were evaluated. The results showed that BDE 209 could be metabolized into debrominated BDEs, methoxylated BDEs (MeO-BDEs) and hydroxylated BDEs (OH-BDEs). Levels of these three metabolites were tissue-dependent. The TH levels, including total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3) and free triiodothyronine (FT3) in plasma, were significantly affected by BDE 209 metabolism. However, only FT4 levels showed a negative correlation with MeO-BDE and OH-BDE metabolites, among which the correlation between FT4 and OH-BDEs was the most significant. (c) 2012 Elsevier B.V. All rights reserved.
WOS记录号	WOS:000308972000004
公开日期	2014-11-04
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/7799]
专题	生态环境研究中心_环境水质学国家重点实验室
推荐引用方式 GB/T 7714	Feng, Chenglian,Xu, Yiping,Zhao, Gaofeng,et al. Relationship between BDE 209 metabolites and thyroid hormone levels in rainbow trout (Oncorhynchus mykiss)[J]. AQUATIC TOXICOLOGY,2012,122:28－35.
APA	Feng, Chenglian,Xu, Yiping,Zhao, Gaofeng,Zha, Jinmiao,Wu, Fengchang,&Wang, Zijian.(2012).Relationship between BDE 209 metabolites and thyroid hormone levels in rainbow trout (Oncorhynchus mykiss).AQUATIC TOXICOLOGY,122,28－35.
MLA	Feng, Chenglian,et al."Relationship between BDE 209 metabolites and thyroid hormone levels in rainbow trout (Oncorhynchus mykiss)".AQUATIC TOXICOLOGY 122(2012):28－35.