MutL associates with Escherichia coli RecA and inhibits its ATPase activity

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	MutL associates with Escherichia coli RecA and inhibits its ATPase activity
	Zhang, Min ; Zhou, Ying ; Li, Tao ; Wang, Hailin ; Cheng, Fang ; Zhou, Yafeng ; Bi, Lijun ; Zhang, Xian-En
刊名	Biochemistry & Molecular Biology; Biophysics
	2012
卷号	517 期号:2 页码:98-103
关键词	RecA MutL Homologous recombination Protein interaction
ISSN号	0003-9861
中文摘要	Different DNA repair systems are known to cooperate to deal with DNA damage. However, the regulatory role of the cross-talk between these pathways is unclear. Here, we have shown that MutL, an essential component of mismatch repair, is a RecA-interacting protein, and that its highly conserved N-terminal domain is sufficient for this interaction. Surface plasmon resonance and capillary electrophoresis analyses revealed that MutL has little effect on RecA-ssDNA filament formation, but dose down-regulate the ATPase activity of RecA. Our findings identify a new role for MutL, and suggest its regulatory role in homologous recombination. (C) 2011 Published by Elsevier Inc.
WOS记录号	WOS:000299146000002
公开日期	2014-11-27
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/8069]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zhang, Min,Zhou, Ying,Li, Tao,et al. MutL associates with Escherichia coli RecA and inhibits its ATPase activity[J]. Biochemistry & Molecular Biology; Biophysics,2012,517(2):98-103.
APA	Zhang, Min.,Zhou, Ying.,Li, Tao.,Wang, Hailin.,Cheng, Fang.,...&Zhang, Xian-En.(2012).MutL associates with Escherichia coli RecA and inhibits its ATPase activity.Biochemistry & Molecular Biology; Biophysics,517(2),98-103.
MLA	Zhang, Min,et al."MutL associates with Escherichia coli RecA and inhibits its ATPase activity".Biochemistry & Molecular Biology; Biophysics 517.2(2012):98-103.