Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana

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	Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana
	Saito, Yoshinori 1; Sasaki, Yoko 1; Komiyama, Teppei 2; Ohsaki, Ayumi 2; Okamoto, Yasuko 1; Gong, Xun3 ; Kuroda, Chiaki 4,5; Tori, Motoo 1
刊名	TETRAHEDRON
	2014-09-02
卷号	70 期号:35 页码:5878-5883
关键词	Asteraceae Ligularia lingiana Sesquiterpenoid Eremophilane Dimer
ISSN号	0040-4020
通讯作者	Gong, X (reprint author), Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China. ; gongxun@mail.kib.ac.cn ; chkkuroda@rikkyo.ac.jp ; tori@ph.bunri-u.ac.jp
产权排序	第三
英文摘要	Five new 12-oxygenated eremophilane sesquiterpenoids bearing a B-ring enone system were isolated from Ligularia lingiana S.W. Liu (Asteraceae) collected in China. Compound 5 was a Diels-Alder adduct of 3 alpha-angeloyloxy-7 beta H-8-oxoeremophila-9,11(13)-dien-12-al and the monoterpene, ocimene. Compound I showed cytotoxic activities against HeLa, HL60, Jurkat, and NIH-3T3 cells at IC50 0.0407, 0.440, 0.313, and 3.48 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Organic
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	HYBRIDUS L GM ; GENETIC DIVERSITY ; CHEMICAL-CONSTITUENTS ; PETASITES COMPONENTS ; SOUTHWESTERN SICHUAN ; HENGDUAN MOUNTAINS ; YUNNAN PROVINCE ; CHINA ; DERIVATIVES ; SESQUITERPENES
收录类别	SCI ; IC
资助信息	Japan Society for the Promotion of Science [21404009]
语种	英语
WOS记录号	WOS:000340336000064
公开日期	2014-10-11
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18306]
专题	昆明植物研究所_资源植物与生物技术所级重点实验室
作者单位	1.Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan 2.Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 4.Rikkyo Univ, Dept Chem, Toshima Ku, Tokyo 1718501, Japan 5.Rikkyo Univ, Res Ctr Smart Mol, Toshima Ku, Tokyo 1718501, Japan
推荐引用方式 GB/T 7714	Saito, Yoshinori,Sasaki, Yoko,Komiyama, Teppei,et al. Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana[J]. TETRAHEDRON,2014,70(35):5878-5883.
APA	Saito, Yoshinori.,Sasaki, Yoko.,Komiyama, Teppei.,Ohsaki, Ayumi.,Okamoto, Yasuko.,...&Tori, Motoo.(2014).Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana.TETRAHEDRON,70(35),5878-5883.
MLA	Saito, Yoshinori,et al."Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana".TETRAHEDRON 70.35(2014):5878-5883.