Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry

	Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry
	Yin, Peiyuan; Xu, Guowang
刊名	expert review of molecular diagnostics
	2013-05-01
卷号	13 期号:4 页码:339-348
关键词	biomarker cancer chromatography mass spectrometry metabolomics translational medicine
ISSN号	1473-7159
通讯作者	许国旺
产权排序	待补充
合作状况	英
英文摘要	early detection is the most effective way to improve the clinical outcome of malignancies. although some tumor markers are now widely used in the clinic, their sensitivity and specificity are still not satisfactory. thus, there is an urgent requirement for the discovery of new tumor markers. by measuring holistic endogenous metabolites, metabolomics can be used for delineating metabolic networks and discovering metabolic markers. chromatography-mass spectrometry is the most widely used tool for metabolomics and has shown great potential for biomarker screening. in this review, the authors summarize: recent advances in the protocols and methodologies of chromatography-mass spectrometry-based metabolomics in the discovery of tumor markers; recently identified tumor metabolic markers for primary liver cancer, gynecologic cancer and genitourinary cancer and their applications; and commonly encountered problems in the translational research of metabolic markers.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	pathology
研究领域[WOS]	pathology
关键词[WOS]	human colorectal-cancer ; differential metabolite discovery ; urinary volatile compounds ; amino-acid profiles ; cell lung-cancer ; hepatocellular-carcinoma ; gas-chromatography ; breast-cancer ; liver-cirrhosis ; bladder-cancer
收录类别	SCI
资助信息	1，1
原文出处	348
语种	英语
WOS记录号	WOS:000318620900010
公开日期	2014-09-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/119657]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Yin, Peiyuan,Xu, Guowang. Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry[J]. expert review of molecular diagnostics,2013,13(4):339-348.
APA	Yin, Peiyuan,&Xu, Guowang.(2013).Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry.expert review of molecular diagnostics,13(4),339-348.
MLA	Yin, Peiyuan,et al."Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry".expert review of molecular diagnostics 13.4(2013):339-348.