Nicotinic acid is an important fine Chemical product which is widely used in medicine, food, animal feed and Fine Chemical . With the rapid development of pharmaceutical and chemical industry, the demand for nicotinic acid increases quickly. But the existed methods haven't satisfied the market needs. Defined by the backward technology of our country and the increasing pressure on environmental protection, it is urgent to develop new, environment compatible synthesis ways with low capital investment. The synthesis methods of nicotinic acid such as vapor-phase oxidation，liquid-phase oxidation and electro-chemical oxidation were described. Usually, costly 3-methlypyridine was used as material in these methods. So we prepared nicotinic acid by ozonolysis of quinoline. In this paper, nicotinic acid was prepared by subliming quinolinic acid which got from ozonolysis of quinoline in the solvent contained glacial acetic acid, acetic ether and water under a mild reaction condition. In our work, the influences of concentrated sulfuric acid and solvents to the yield of nicotinic acid were investigated. The optimum technological material molar ratio of n (concentrated sulfuric acid): n (quinoline) =1.1~1.5:1; V(glacial acetic acid):V(acetic ether) = 3:1. Under the above conditions the yield of nicotinic acid is up to 65%, and the relative mass fraction is not less than 95% detected by HPLC.