Identification and expression profiles of prdm1 in medaka Oryzias latipes | |
Zhao, Haobin1,2; Zhang, Xiaosha1; Cheng, Nana1; Duan, Jundan1; Wang, Jialin1; Nagahama, Yoshitaka2,3; Zhong, Xueping1; Zhou, Qingchun1; Wang, Yaping4 | |
刊名 | MOLECULAR BIOLOGY REPORTS |
2014-02-01 | |
卷号 | 41期号:2页码:617-626 |
关键词 | Medaka Zebrafish Prdm1a Prdm1b Embryogenesis Gene expression Immune response |
ISSN号 | 0301-4851 |
通讯作者 | Zhao, HB (reprint author), Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China. |
中文摘要 | Mouse Prdm1, also known as Blimp1, plays important roles in maturation and survival of lymphoid cells, as well as in organogenesis of muscle, limb, sensor organs and primordial germ cells. The homologues of mouse prdm1 have been identified in a diverse of animals including zebrafish and fugu. Here, we report the identification and expression profiles of two homologues of prdm1, namely prdm1a and prdm1b in medaka, Oryzias latipes. The transcripts of prdm1a and prdm1b were detectable in all the tissues including immune organs such as gill, spleen, kidney, liver and intestine that we have checked on. The transcripts of prdm1a could be detected in the embryonic shield at mid-gastrula stage and later in the somite, eye, otic vesicle, branchial arches, fin, intestine and cloaca during embryogenesis using in situ hybridization. Moreover, the expression of prdm1a in the liver of both medaka and zebrafish could be up-regulated by the immune stimuli including lipopolysaccharide, polyI:C and the grass carp reovirus, similarly to the up-regulation of IL1B. These results indicate that Prdm1a may play important roles in embryogenesis and also in immune response in fish. |
英文摘要 | Mouse Prdm1, also known as Blimp1, plays important roles in maturation and survival of lymphoid cells, as well as in organogenesis of muscle, limb, sensor organs and primordial germ cells. The homologues of mouse prdm1 have been identified in a diverse of animals including zebrafish and fugu. Here, we report the identification and expression profiles of two homologues of prdm1, namely prdm1a and prdm1b in medaka, Oryzias latipes. The transcripts of prdm1a and prdm1b were detectable in all the tissues including immune organs such as gill, spleen, kidney, liver and intestine that we have checked on. The transcripts of prdm1a could be detected in the embryonic shield at mid-gastrula stage and later in the somite, eye, otic vesicle, branchial arches, fin, intestine and cloaca during embryogenesis using in situ hybridization. Moreover, the expression of prdm1a in the liver of both medaka and zebrafish could be up-regulated by the immune stimuli including lipopolysaccharide, polyI:C and the grass carp reovirus, similarly to the up-regulation of IL1B. These results indicate that Prdm1a may play important roles in embryogenesis and also in immune response in fish. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Biochemistry & Molecular Biology |
研究领域[WOS] | Biochemistry & Molecular Biology |
关键词[WOS] | INDUCED MATURATION PROTEIN-1 ; TRANSCRIPTIONAL REPRESSOR BLIMP1/PRDM1 ; SECRETING PLASMA-CELLS ; TUMOR-SUPPRESSOR GENE ; PRIMORDIAL GERM-CELLS ; B-CELL ; BLIMP-1 EXPRESSION ; NEURAL CREST ; DIFFERENTIATION ; LYMPHOCYTES |
收录类别 | SCI |
资助信息 | National Natural Science Foundation of China [31272645, 30972254, 31071997]; Japan Society for the Promotion of Science |
语种 | 英语 |
WOS记录号 | WOS:000330860900006 |
公开日期 | 2014-08-08 |
内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/20051] |
专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
作者单位 | 1.Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China 2.Japan Soc Promot Sci, Tokyo 1028471, Japan 3.Ehime Univ, Inst Collaborat Relat, Matsuyama, Ehime 7908577, Japan 4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Fresh Water Ecol & Biotechnol, Wuhan 430074, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Haobin,Zhang, Xiaosha,Cheng, Nana,et al. Identification and expression profiles of prdm1 in medaka Oryzias latipes[J]. MOLECULAR BIOLOGY REPORTS,2014,41(2):617-626. |
APA | Zhao, Haobin.,Zhang, Xiaosha.,Cheng, Nana.,Duan, Jundan.,Wang, Jialin.,...&Wang, Yaping.(2014).Identification and expression profiles of prdm1 in medaka Oryzias latipes.MOLECULAR BIOLOGY REPORTS,41(2),617-626. |
MLA | Zhao, Haobin,et al."Identification and expression profiles of prdm1 in medaka Oryzias latipes".MOLECULAR BIOLOGY REPORTS 41.2(2014):617-626. |
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