Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr

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	Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr
	Huang, Sheng-Zhuo 1,2; Zhang, Xuan 3; Ma, Qing-Yun 1; Peng, Hua2 ; Zheng, Yong-Tang 3; Hu, Jiang-Miao2 ; Dai, Hao-Fu 1; Zhou, Jun2 ; Zhao, You-Xing 1
刊名	FITOTERAPIA
	2014-06-01
卷号	95 页码:34-41
关键词	Excoecaria acerifolia Euphorbiaceae Excoecafolin Anti-HIV-1 Chemotaxonomy
ISSN号	0367-326X
通讯作者	Zhou,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China. ; junzhou3264@126.com ; zhaoyx1011@163.com
英文摘要	Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerzfolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 mu M, SI >1,836.9,431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates. (C) 2014 Elsevier B.V. All rights reserved.
学科主题	Chemistry, Medicinal ; Pharmacology & Pharmacy
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	DAPHNE-ACUTILOBA REHD ; SKIN IRRITANTS ; ACTIVE PRINCIPLES ; MOUSE SKIN ; ACERIFOLIA ; AGALLOCHA ; ESTERS ; LATEX ; THYMELAEACEAE ; COCARCINOGENS
收录类别	SCI
资助信息	National Natural Science Foundation of China [31300294];Special Fund for Agro-scientific Research in the Public Interest [201303117];National Support Science and Technology Subject [2013BAI11804];Major Technology Project of Hainan [ZDZX2013008-4, ZDZX2013023-1]
语种	英语
WOS记录号	WOS:000336819400005
公开日期	2014-07-28
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/18187]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Huang, Sheng-Zhuo,Zhang, Xuan,Ma, Qing-Yun,et al. Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr[J]. FITOTERAPIA,2014,95:34-41.
APA	Huang, Sheng-Zhuo.,Zhang, Xuan.,Ma, Qing-Yun.,Peng, Hua.,Zheng, Yong-Tang.,...&Zhao, You-Xing.(2014).Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr.FITOTERAPIA,95,34-41.
MLA	Huang, Sheng-Zhuo,et al."Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr".FITOTERAPIA 95(2014):34-41.